QTERN Dosage

Prior to Initiation of QTERN

Assess renal function prior to initiation of QTERN therapy and periodically thereafter.

Assess volume status. In patients with volume depletion, correct this condition before initiating QTERN.

Dosage

For patients not already taking dapagliflozin, the recommended starting dose of QTERN is a 5 mg dapagliflozin/5 mg saxagliptin tablet taken orally once daily in the morning with or without food.

In patients tolerating 5 mg dapagliflozin and 5 mg saxagliptin once daily who require additional glycemic control, the QTERN dose can be increased to 10 mg dapagliflozin/5 mg saxagliptin tablet once daily in the morning with or without food.

Swallow whole. Do not crush, cut or chew QTERN tablets.

Patients with Renal Impairment

No dose adjustment is needed in patients with an estimated glomerular filtration rate (eGFR) greater than or equal to 45 mL/min/1.73 m2.

QTERN is contraindicated in patients with an eGFR less than 45 mL/min/1.73 m2.

Use with Strong CYP3A4/5 Inhibitors

Do not coadminister QTERN with strong cytochrome P450 3A4/5 inhibitors (e.g., ketoconazole, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, and telithromycin).

Temporary Interruption for Surgery

Withhold QTERN for at least 3 days, if possible, prior to major surgery or procedures associated with prolonged fasting. Resume QTERN when the patient is clinically stable and has resumed oral intake.