Pulmozyme Dosage

Generic name: DORNASE ALFA 1mg in 1mL
Dosage form: inhalation solution
Drug class: Miscellaneous respiratory agents

Medically reviewed by Drugs.com. Last updated on Jul 9, 2024.

Recommended Dosage

The recommended dosage, in most cystic fibrosis patients, is 2.5 mg (one single-dose ampule) inhaled once daily using a recommended jet nebulizer connected to an air compressor system or via a vibrating mesh nebulizer.

Some patients may benefit from twice daily administration.

Administration Instructions

Nebulizer Information

Administer PULMOZYME via a jet nebulizer connected to an air compressor with an adequate air flow and equipped with a mouthpiece or suitable face mask, or via a vibrating mesh nebulizer. Refer to Table 1 for the recommended Jet Nebulizers or Vibrating Mesh Nebulizers for use with PULMOZYME. No data are currently available to support the administration of PULMOZYME with other nebulizer systems.
The eRapid Nebulizer System should only be used by adults and pediatric patients who can use a mouthpiece, and not by younger patients who need a mask to inhale PULMOZYME.
Use the selected nebulizer in accordance with the manufacturer's instruction manual.
Refer to the manufacturer's instruction manual on the use, maintenance, and replacement of the equipment, including cleaning and disinfection procedures for the selected nebulizer.
For additional information, refer to the selected nebulizer manufacturer's instruction manual.

Table 1. Recommended Jet Nebulizers or Vibrating Mesh Nebulizers for Use with PULMOZYME
Jet Nebulizer*	Compressor
* Follow the selected nebulizer manufacturer's instruction manual. † Patients who are unable to inhale or exhale orally throughout the entire nebulization period may use the PARI BABY™ nebulizer. ‡ Consisting of the eRapid® Nebulizer Handset with eBase™ Controller. Avoid use in patients who need a mask to inhale PULMOZYME.
Hudson T Up-draft II®	Pulmo-Aide® or legally marketed compressor of identical pressure and flow rate (maximum 30 psi, 12 LPM).
Marquest Acorn II®
PARI LC® Plus	PARI PRONEB® or legally marketed compressor of identical pressure and flow rate (maximum 24 psi, 9 LPM).
PARI BABY™†
Durable Sidestream®	MOBILAIRE™, Porta-NEB® or legally marketed compressor of identical pressure and flow rate (maximum 45 psi, 7 LPM).
Vibrating Mesh Nebulizers*
eRapid® Nebulizer System‡
Innospire Go
Pulmogine Vibrating Mesh Nebulizer
AireHealth Nebulizer™
Intelligent Mesh Nebulizer

PULMOZYME Information

Each PULMOZYME ampule should be squeezed prior to use in order to check for leaks. Discard ampules if the solution is cloudy or discolored. Once opened, the entire contents of the ampule must be used or discarded.
Do not dilute or mix PULMOZYME with other drugs in the nebulizer. Mixing of PULMOZYME with other drugs could lead to adverse physicochemical and/or functional changes in PULMOZYME or the admixed compound.