Phendimetrazine Dosage

Medically reviewed by Drugs.com. Last updated on Jul 24, 2023.

Usual Adult Dose for Obesity

Extended-release: 105 mg orally once a day, 30 to 60 minutes before morning meal

Immediate-release: 35 mg orally 2 or 3 times a day, one hour before meals

• Dosage should be individualized to obtain an adequate response with the lowest effective dose; for some patients, 17.5 mg per dose may be adequate

Maximum dose: 70 mg orally 3 times a day, one hour before meals

Comments:

• For use as monotherapy only; indicated for short term use, e.g. a few weeks.

Uses: Management of exogenous obesity as a short-term adjunct in a regimen of weight reduction based on caloric restriction in patients with:

• an initial BMI of 30 kg/m2 or greater OR
• an initial BMI of 27 kg/m2 or greater in the presence of other risk factors (e.g., hypertension, diabetes, hyperlipidemia) who have not responded to appropriate weight reducing regimen (diet and/or exercise) alone.

Usual Pediatric Dose for Obesity

Extended-release (17 years and older): See Adult Dose

Renal Dose Adjustments

Data not available; Use with caution.

Liver Dose Adjustments

Data not available

Dose Adjustments

Elderly: Dose selection should be cautious

When Tolerance to Anorectic Effect Develops (usually occurs within a few weeks):

• Discontinue treatment; maximum recommended dose should not be exceeded.

Precautions

Extended-release: Safety and efficacy have not been established in patients younger than 17 years.

Immediate-release: Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule III

Dialysis

Data not available

Other Comments

Administration Advice:

• Immediate-release tablet: Take orally 2 or 3 times a day 1 hour before meals
• Extended-release capsules: Take orally 30 to 60 minutes before morning meal

General:

• This drug should be used as monotherapy; efficacy with other anorectic agents has not been studied and the combine use may have the potential for serious cardiac problems.

Patient Advice:

• Patients should be instructed to read the patient labeling.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer