Lemborexant Dosage

Medically reviewed by Drugs.com. Last updated on May 23, 2024.

Usual Adult Dose for Insomnia

5 mg orally once a day at bedtime

• Maximum dose: 10 mg once at bedtime

Use: For the treatment of patients with insomnia, characterized by difficulties with sleep onset and/or sleep maintenance.

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Mild liver dysfunction: No adjustment recommended.
Moderate liver dysfunction: Maximum dose 5 mg/day at bedtime
Severe liver dysfunction: Not recommended.

Dose Adjustments

USE WITH STRONG OR MODERATE CYP450 3A4 INHIBITORS: Not recommended.

USE WITH WEAK CYP450 3A4 INHIBITORS: Up to 5 mg orally once a day immediately prior to bedtime

• Maximum dose: 5 mg/day

USE WITH STRONG OR MODERATE CYP450 3A4 INDUCERS: Not recommended.

Precautions

CONTRAINDICATIONS: Patients with narcolepsy

Safety and efficacy have not been established in children.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule IV

Dialysis

Data not available

Other Comments

Administration advice:

• Take immediately before going to bed.
• Dose should be taken with at least 7 hours remaining before the planned time of awakening.
• Time to sleep onset may be delayed if taken with or soon after a meal.

Storage requirements:

• Store at 20C to 25C.

Patient advice:

• Read the approved patient labeling.
• Take only when preparing for or getting into bed and only if you can stay in bed for a full night (at least 7 hours) before being active again.
• The effect of this drug may be delayed if taken with or soon after a meal.
• This drug can impair daytime wakefulness even when used as prescribed. The risk of daytime impairment increases if you do not have a full night of sleep.
• Use caution if you are driving and doing activities requiring complete mental alertness.
• Increased drowsiness may increase your risk of falling.
• This drug may cause complex sleep behaviors, including sleepwalking, sleep-driving, preparing and eating food, making phone calls, or having sex while not being fully awake. Discontinue and notify your healthcare provider immediately if you develop any of these symptoms.
• Report any worsening of depression or suicidal thoughts immediately.
• There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to this drug. Talk to your doctor if you are pregnant.
• Do not consume alcohol while taking this drug.
• Tell your doctor all your medical conditions, and all the other drugs you are taking, with or without a prescription.
• Do not increase the prescribed dose of this drug and inform your doctor if you think the drug "does not work".

Frequently asked questions

• What are the strongest sleeping pills?
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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer