Journavx Dosage

Generic name: Suzetrigine 50mg
Dosage form: tablet, film coated
Drug class: Miscellaneous analgesics

Medically reviewed by Drugs.com. Last updated on Feb 6, 2025.

Recommended Dosage and Administration Instructions

Swallow JOURNAVX tablets whole and do not chew or crush.

The recommended starting dose of JOURNAVX is 100 mg orally. Take the starting dose on an empty stomach at least 1 hour before or 2 hours after food to avoid delay in onset of action. Clear liquids may be consumed during this time (e.g., water, apple juice, vegetable broth, tea, black coffee).

Starting 12 hours after the initial dose, take 50 mg of JOURNAVX orally every 12 hours. Take these doses with or without food.

Avoid food or drink containing grapefruit during treatment with JOURNAVX.

Use JOURNAVX for the shortest duration, consistent with individual patient treatment goals. Use of JOURNAVX for the treatment of moderate to severe acute pain has not been studied beyond 14 days.

Recommended Dosage in Patients with Hepatic Impairment

The recommended dosage of JOURNAVX in patients with hepatic impairment is described in Table 1.

Table 1: Recommended JOURNAVX Dosage in Patients with Hepatic Impairment
Degree of Hepatic Impairment (HI)	Recommended Dosage
Severe HI (Child-Pugh Class C)	Avoid use.
Moderate HI (Child-Pugh Class B)	Dose 1: The recommended starting dose of JOURNAVX is 100 mg taken orally. Take the starting dose on an empty stomach at least 1 hour before or 2 hours after food. Clear liquids may be consumed during this time (e.g., water, apple juice, vegetable broth, tea, black coffee). Doses 2, 3, and 4: Starting 12 hours after the initial dose, take 50 mg of JOURNAVX orally every 12 hours. Take these doses with or without food. Dose 5 and Subsequent Doses: Starting 12 hours after Dose 4, take 50 mg of JOURNAVX orally every 24 hours. Take these dose(s) with or without food.
Mild HI (Child-Pugh Class A)	The recommended dosage is the same as in those with normal hepatic function.

Dosage Modifications for CYP3A Inhibitors

JOURNAVX is contraindicated in patients taking strong CYP3A inhibitors. When JOURNAVX is administered to patients taking moderate CYP3A inhibitors reduce the JOURNAVX dose, as described below:

Dose 1: The recommended starting dose of JOURNAVX is 100 mg orally. Take the starting dose on an empty stomach at least 1 hour before or 2 hours after food. Clear liquids may be consumed during this time (e.g., water, apple juice, vegetable broth, tea, black coffee).

Doses 2, 3, and 4: Starting 12 hours after the initial dose, take 50 mg of JOURNAVX orally every 12 hours. Take these doses with or without food.

Dose 5 and Subsequent Doses: Starting 12 hours after Dose 4, take 50 mg of JOURNAVX orally every 24 hours. Take these dose(s) with or without food.

Avoid food or drink containing grapefruit during treatment with JOURNAVX.

Recommendations Regarding Missed Dose(s)

For patients on the standard recommended dosing schedule:

If a dose is missed, take the missed dose as soon as possible and then take the next scheduled dose at the recommended time.
If two or more doses are missed, take 100 mg and then take the next scheduled dose at the recommended time.

For patients with moderate hepatic impairment or patients taking moderate CYP3A inhibitors, if a dose is missed, take the missed dose as soon as possible. If the next scheduled dose is within 6 hours, skip the next scheduled dose, and take the subsequent doses at the recommended time.