Glyxambi Dosage

Testing Prior to Initiation of GLYXAMBI

• Assess renal function before initiating GLYXAMBI and as clinically indicated.
• Assess volume status. In patients with volume depletion, correct this condition before initiating GLYXAMBI.

Recommended Dosage and Administration

The recommended dosage of GLYXAMBI is 10 mg empagliflozin/5 mg linagliptin once daily in the morning, taken with or without food. GLYXAMBI may be increased to 25 mg empagliflozin/5 mg linagliptin once daily for additional glycemic control.

Dosage Recommendations in Patients with Renal Impairment

GLYXAMBI is not recommended for use in patients with an eGFR less than 30 mL/min/1.73 m2 and contraindicated in patients on dialysis.

Recommendations Regarding Missed Dose

• ​If a dose is missed, instruct patients to take the dose as soon as possible.
• ​Do not double up the next dose.

Temporary Interruption for Surgery

​Withhold GLYXAMBI for at least 3 days, if possible, prior to major surgery or procedures associated with prolonged fasting. Resume GLYXAMBI when the patient is clinically stable and has resumed oral intake.