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Dapagliflozin / Saxagliptin Dosage

Medically reviewed by Drugs.com. Last updated on Jun 18, 2024.

Applies to the following strengths: 5 mg-5 mg; 10 mg-5 mg

Usual Adult Dose for Diabetes Type 2

For patients not already taking dapagliflozin:
Initial dose: dapagliflozin 5 mg/saxagliptin 5 mg orally once a day in the morning

For patients tolerating dapagliflozin 5 mg and saxagliptin 5 mg once a day who require additional glycemic control: dapagliflozin 10 mg/saxagliptin 5 mg orally once a day in the morning

Comments:


Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Renal Dose Adjustments

eGFR: 45 mL/min/1.73 m2 or greater: No adjustment recommended
eGFR less than 45 mL/min/1.73 m2: Contraindicated

Liver Dose Adjustments

Use with caution, especially in patients with severe hepatic impairment.

Benefit-risk for use in severe hepatic impairment should be individually assessed since safety and efficacy in this population has not been studied.

Dose Adjustments

Elderly: Dose adjustment may be required due to renal function

Combination use with insulin or an insulin secretagogue: A lower dose of insulin or insulin secretagogue may be required to minimize the risk of hypoglycemia

Concomitant Use with Strong CYP450 3A4/5 Inhibitors: Not Recommended

Precautions

CONTRAINDICATIONS:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Contraindicated

Other Comments

Administration advice:



General:

Monitoring:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.