Cocaine Nasal Dosage

Usual Adult Dose for Local Anesthesia

Place 2 soaked cottonoid pledgets (40 mg per pledget) in each nasal cavity for a total dose of 160 mg.

Maximum dose: 160 mg (4 pledgets), or 3 mg/kg, for any one procedure/surgery

Comments: The recommended size of cottonoid pledgets measure 1.3 cm x 4 cm.

Use: Induction of local anesthesia of the mucous membranes when performing diagnostic procedures and surgeries on or through the nasal cavities.

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

No adjustment recommended; monitor for adverse reactions such as headache, epistaxis, and clinically-relevant increases in heart rate or blood pressure and do not administer a second dose within 24 hours of the first dose.

Precautions

US BOXED WARNING:

• ABUSE AND DEPENDENCE: Central nervous system (CNS) stimulants, including cocaine hydrochloride, have a high potential for abuse and dependence.

CONTRAINDICATIONS:

• Hypersensitivity to the active component, any of the ingredients, or any other ester-based anesthetic

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule II

Dialysis

Data not available

Other Comments

Administration advice:

• This drug should not be applied to damaged mucosa or open wounds.
• Place 2 pledgets in each nasal cavity against the septum.
• Leave pledgets in place for up to 20 minutes before removing and continuing with the procedure.
• Discard pledgets and dispose of any unused solution in accordance with institutional procedures for Schedule II products.

Storage requirements: Do not freeze.

Reconstitution/preparation techniques: Pour the entire contents of one 4 mL (160 mg) bottle into a small container and soak 4 cottonoid pledgets until the solution is fully absorbed.

Monitoring:

• General: Vital signs
• Nervous system: Seizure development

Patient advice: Advise pregnant women of the potential risk to a fetus.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer