Apalutamide Dosage

Medically reviewed by Drugs.com. Last updated on Sep 8, 2023.

Usual Adult Dose for Prostate Cancer

240 mg orally once a day

Comments:

• Patients should receive a gonadotropin-releasing hormone (GnRH) analog concurrently or have had a bilateral orchiectomy.

Uses:

• For the treatment of metastatic castration-sensitive prostate cancer (mCSPC)
• For the treatment of non-metastatic castration-resistant prostate cancer (nmCRPC)

Renal Dose Adjustments

Mild to moderate renal impairment: No adjustment required.
Severe or end-stage renal impairment: Data not available

Liver Dose Adjustments

Mild (Child-Pugh A) or moderate (Child-Pugh) hepatic impairment: No adjustment recommended.
Severe (Child-Pugh C) hepatic impairment: Data not available

Dose Adjustments

If a patient experiences a Grade 3 or greater toxicity or an intolerable side effect, hold dosing until symptoms improve to Grade 1 or less or original grade, then resume at the same dose or a reduced dose (180 mg or 120 mg).

Precautions

CONTRAINDICATIONS:

• None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• Swallow tablets whole.
• May be taken with or without food.
• Take at the same time each day.
• If a dose is missed, take the normal dose as soon as possible on the same day and return to normal schedule the following day; extra tablets to make up the missed dose should not be taken.

Storage requirements:

• Store in original package.
• Do not discard desiccant.
• Protect from light and moisture.

Patient advice:

• Inform your healthcare provider if you develop a rash.
• Immediately contact your healthcare provider if you experience a seizure; engaging in any activity where sudden loss of consciousness could cause serious harm to yourself or others due the risk of seizures.
• This drug can be harmful to a developing fetus; if having sex with female partners of reproductive potential, use effective contraception during treatment and for 3 months after the last dose; use a condom if having sex with a pregnant woman.
• Do not donate sperm during therapy and for 3 months after the last done; this drug may impair male fertility.

Frequently asked questions

• How long do you have to take Erleada (apalutamide) for?
• How effective is Erleada (apalutamide)?
• What type of prostate cancer is Erleada used to treat?

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer