Thyrogen Disease Interactions
There are 2 disease interactions with Thyrogen (thyrotropin alpha).
Thyrotropin alfa (applies to Thyrogen) heart disease
Moderate Potential Hazard, Moderate plausibility.
Thyrotropin alfa is known to cause a transient (over 7 to 14 days) but significant rise in serum thyroid hormone concentration when given to patients who have substantial thyroid tissue still in situ or functional thyroid cancer metastases, There have been reports of death in non-thyroidectomized patients and in patients with distant metastatic thyroid cancer in which events leading to death occurred within 24 hours after administration of the drug. Patients with residual thyroid tissue at risk for thyrotropin alfa-induced hyperthyroidism include the elderly and those with a known history of heart disease. Hospitalization for administration of therapy and post-administration observation in patients at risk should be considered.
Thyrotropin alfa (applies to Thyrogen) dialysis
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: hemodialysis
The elimination of thyrotropin alfa is significantly slower in dialysis-dependent end stage renal disease (ESRD) patients, resulting in prolonged elevation of TSH levels.
Thyrogen drug interactions
There are 54 drug interactions with Thyrogen (thyrotropin alpha).
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
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