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Granix Disease Interactions

There are 3 disease interactions with Granix (tbo-filgrastim).

Major

CSF (applies to Granix) glomerulonephritis

Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Although it has been reported that renal dysfunction has no effect on the pharmacokinetics of colony stimulating factors (CSF), filgrastim and pegfilgrastim may cause glomerulonephritis. Symptoms include swelling of the face or ankles, dark colored urine, or blood in the urine, or a decrease in urine production. Advise patients to report signs or symptoms of glomerulonephritis immediately. Monitoring of patients with renal dysfunction is recommended.

References

  1. (2002) "Product Information. Neupogen (filgrastim)." Amgen
  2. (2002) "Product Information. Neulasta (pegfilgrastim)." Amgen
  3. (2013) "Product Information. Granix (tbo-filgrastim)." Teva Pharmaceuticals USA
Moderate

Tbo-filgrastim (applies to Granix) sickle cell disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Sickle Cell Anemia

Severe and sometimes fatal sickle cell crises have been reported in sickle cell disease patients receiving filgrastim products. Consider the potential risks and benefits prior to initiating therapy in these patients.

References

  1. (2002) "Product Information. Neupogen (filgrastim)." Amgen
  2. (2013) "Product Information. Granix (tbo-filgrastim)." Teva Pharmaceuticals USA
Moderate

Tbo-filgrastim (applies to Granix) tumor growth

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Myelodysplastic Disease

Tbo-filgrastim can act as a growth factor for any tumor type, including myeloid malignancies and myelodysplasia disease, diseases for which its use has not been approved.

References

  1. (2013) "Product Information. Granix (tbo-filgrastim)." Teva Pharmaceuticals USA

Granix drug interactions

There are 168 drug interactions with Granix (tbo-filgrastim).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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