Carbenicillin Disease Interactions
There are 5 disease interactions with carbenicillin.
Antibiotics (applies to carbenicillin) colitis
Major Potential Hazard, Moderate plausibility. Applicable conditions: Colitis/Enteritis (Noninfectious)
Clostridioides difficile-associated diarrhea (CDAD), formerly pseudomembranous colitis, has been reported with almost all antibacterial drugs and may range from mild diarrhea to fatal colitis. The most common culprits include clindamycin and lincomycin. Antibacterial therapy alters the normal flora of the colon, leading to overgrowth of C difficile, whose toxins A and B contribute to CDAD development. Morbidity and mortality are increased with hypertoxin-producing strains of C difficile; these infections can be resistant to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea after antibacterial use. Since CDAD has been reported to occur more than 2 months after antibacterial use, careful medical history is necessary. Therapy with broad-spectrum antibacterials and other agents with significant antibacterial activity should be administered cautiously in patients with history of gastrointestinal disease, particularly colitis; pseudomembranous colitis (generally characterized by severe, persistent diarrhea and severe abdominal cramps, and sometimes associated with the passage of blood and mucus), if it occurs, may be more severe in these patients and may be associated with flares in underlying disease activity. Antibacterial drugs not directed against C difficile may need to be stopped if CDAD is suspected or confirmed. Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile, and surgical evaluation should be started as clinically indicated.
Beta-lactams (oral) (applies to carbenicillin) renal dysfunction
Moderate Potential Hazard, High plausibility.
Most beta-lactam antibiotics are eliminated by the kidney as unchanged drug and, in some cases, also as metabolites. The serum concentrations of beta-lactam antibiotics and their metabolites may be increased and the half-lives prolonged in patients with impaired renal function. Dosage adjustments may be necessary and modifications should be based on the degree of renal impairment as well as severity of infection in accordance with the individual product package labeling. Renal function tests should be performed periodically during prolonged and/or high-dose therapy, since nephrotoxicity and alterations in renal function have occasionally been associated with the use of these drugs.
Carbenicillin (applies to carbenicillin) renal dysfunction
Moderate Potential Hazard, High plausibility.
Carbenicillin is primarily excreted by the kidney. Patients with severe renal impairment (CrCl < 10 mL/min) generally have markedly reduced concentrations of the drug in the urine and the renal parenchyma. Because of the risk of therapeutic failure from inadequate urinary drug concentrations, use of carbenicillin is not recommended for the treatment of urinary tract infection in patients with severely impaired renal function.
Carbenicillin (applies to carbenicillin) sodium
Moderate Potential Hazard, High plausibility. Applicable conditions: Hypernatremia, Congestive Heart Failure, Hypertension, Fluid Retention
Each 382 mg tablet of carbenicillin indanyl sodium contains approximately 23 mg (1 mEq) of sodium. The sodium content should be considered in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.
Penicillins (applies to carbenicillin) hemodialysis
Moderate Potential Hazard, High plausibility.
Penicillin antibiotics (except for agents in the penicillinase-resistant class) are removed by hemodialysis. Doses should either be scheduled for administration after dialysis or supplemental doses be given after dialysis.
Carbenicillin drug interactions
There are 34 drug interactions with carbenicillin.
Carbenicillin alcohol/food interactions
There are 2 alcohol/food interactions with carbenicillin.
More about carbenicillin
- Check interactions
- Compare alternatives
- Side effects
- Dosage information
- During pregnancy
- Drug class: antipseudomonal penicillins
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
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