Antipseudomonal penicillins

Antipseudomonal penicillins are antimicrobial agents, which are used to treat pseudomonal infections. They have the activity of penicillins and aminopenicillins, and additional activity against Pseudomonas, Enterococcus and Klebsiella.

Antipseudomonal penicillins are usually given with beta-lactamase inhibitors because like other penicillins they are susceptible to hydrolysis by beta-lactamases (therefore are not consistently active against Staphylococcus, some gram-negative rods and certain beta-lactamse producing gram-negative anaerobes).

These penicillins when given with aminoglycosides work effectively and avoid development of resistance strains of bacteria.