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Brenzavvy Disease Interactions

There are 3 disease interactions with Brenzavvy (bexagliflozin).

Major

Bexagliflozin (applies to Brenzavvy) dialysis

Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Bexagliflozin is contraindicated in patients on dialysis, and is not recommended in patients with an eGFR less than 30 mL/min/1.73 m2 due to the decline of the glucose lowering effect of this drug and reduction in
urine output in these patients.

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Moderate

Bexagliflozin (applies to Brenzavvy) hypotension

Moderate Potential Hazard, Moderate plausibility.

Bexagliflozin can cause intravascular volume contraction which may sometimes manifest as symptomatic hypotension or acute transient changes in creatinine. There have been postmarketing reports of acute kidney injury, some requiring hospitalization and dialysis, in patients with type 2 diabetes mellitus receiving SGLT2 inhibitors. Patients with impaired renal function (eGFR less than 60 mL/min/1.73 m2), elderly patients, patients with low systolic blood pressure, or patients on loop diuretics may be at increased risk for volume depletion or hypotension. Before initiating bexagliflozin in patients with one or more of these characteristics, assess volume status and renal function. In patients with volume depletion, correct this condition before treatment initiation.

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Moderate

Bexagliflozin (applies to Brenzavvy) liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Bexagliflozin has not been studied in patients with severe hepatic impairment and is not recommended for use in this patient population. The recommended dosage for patients with mild to moderate hepatic impairment is the
same as the recommended dosage for patients with normal hepatic function.

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Brenzavvy drug interactions

There are 364 drug interactions with Brenzavvy (bexagliflozin).

Brenzavvy alcohol/food interactions

There is 1 alcohol/food interaction with Brenzavvy (bexagliflozin).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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