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Tresiba Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Tresiba (insulin degludec) Ozempic (semaglutide) Mounjaro (tirzepatide)
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Tresiba (insulin degludec) Ozempic (semaglutide) Mounjaro (tirzepatide)
Prescription only

Tresiba contains insulin degludec, an ultra-long-acting insulin that starts to work 60 minutes after administration and keeps working for up to 42 hours. Tresiba is approved for use in adults and... View more

Prescription only

Ozempic lowers blood sugar levels by mimicking the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It is... View more

Prescription only

Prescribed for Weight Loss (Obesity/Overweight), Type 2 Diabetes. Mounjaro may also be used for purposes not listed in this medication guide.

More about Tresiba (insulin degludec) More about Ozempic (semaglutide) More about Mounjaro (tirzepatide)
Ratings & Reviews

Tresiba has an average rating of 4.3 out of 10 from a total of 152 ratings on Drugs.com. 29% of reviewers reported a positive effect, while 56% reported a negative effect.

Ozempic has an average rating of 6.7 out of 10 from a total of 1489 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 22% reported a negative effect.

Mounjaro has an average rating of 8.6 out of 10 from a total of 1236 ratings on Drugs.com. 80% of reviewers reported a positive effect, while 6% reported a negative effect.

View all 152 reviews

View all 1489 reviews

View all 1236 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Tresiba side effects

View all Ozempic side effects

View all Mounjaro side effects
Drug Class
Generic Availability

N/A

No lower cost generic approved

No lower cost generic approved
Pricing and Coupons * Prices are without insurance
Quantity 15 mL
Strength 100 units/mL
Per unit* $36.00
Cost* $540.05

View all Tresiba prices

Quantity 1.5 mL
Strength 2 mg/1.5 mL (0.25 mg or 0.5 mg dose)
Per unit* $700.49
Cost* $1,050.73

View all Ozempic prices

Quantity 2 mL
Strength 2.5 mg/0.5 mL
Per unit* $568.27
Cost* $1,136.53

View all Mounjaro prices

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Dosage Forms
  • Subcutaneous solution
  • Subcutaneous solution
  • Subcutaneous solution
Brand Names

N/A

 Other semaglutide brands include: Rybelsus, Wegovy Other tirzepatide brands include: Zepbound
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

25 hours

168 hours

120 hours
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
Drug Interactions

A total of 390 drugs are known to interact with Tresiba:

  • 15 major drug interactions (39 brand and generic names)
  • 354 moderate drug interactions (1876 brand and generic names)
  • 21 minor drug interactions (210 brand and generic names)

A total of 273 drugs are known to interact with Ozempic:

  • 15 major drug interactions (34 brand and generic names)
  • 257 moderate drug interactions (1448 brand and generic names)
  • 1 minor drug interactions (10 brand and generic names)

A total of 414 drugs are known to interact with Mounjaro:

  • 15 major drug interactions (34 brand and generic names)
  • 398 moderate drug interactions (2268 brand and generic names)
  • 1 minor drug interactions (10 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more
  • Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more
  • Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more
  • Tirzepatide may affect the absorption of other medications that you take by mouth. In some cases... View more
  • Talk to your doctor before using alcohol together with tirzepatide. Alcohol may affect blood... View more
Disease Interactions
First Approval Date

N/A

N/A

N/A
WADA Class View classifications

N/A

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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