Comparing Rybelsus vs Xigduo XR
| Rybelsus (semaglutide) | Xigduo XR (dapagliflozin / metformin) |
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| Rybelsus (semaglutide) | Xigduo XR (dapagliflozin / metformin) |
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Prescription only
Rybelsus (semaglutide) is an oral medicine that can be used as a first-line medication to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It works by mimicking the... View more |
Prescription only
Prescribed for Type 2 Diabetes, Heart Failure. Xigduo XR may also be used for purposes not listed in this medication guide. |
Related suggestions Type 2 Diabetes
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| More about Rybelsus (semaglutide) | More about Xigduo XR (dapagliflozin / metformin) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Rybelsus has an average rating of 6.4 out of 10 from a total of 283 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 24% reported a negative effect. |
Xigduo XR has an average rating of 7.3 out of 10 from a total of 17 ratings on Drugs.com. 71% of reviewers reported a positive effect, while 24% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Rybelsus side effects |
View all Xigduo XR side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Rybelsus prices |
View all Xigduo XR prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other semaglutide brands include: Ozempic, Wegovy |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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168 hours |
12.9 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 273 drugs are known to interact with Rybelsus:
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A total of 477 drugs are known to interact with Xigduo XR:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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September 20, 2019 |
October 29, 2014 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.