Comparing Prozac vs Zoloft
| Prozac (fluoxetine) | Zoloft (sertraline) |
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| Prozac (fluoxetine) | Zoloft (sertraline) |
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Prescription only
Prozac may be used for the treatment of depression and other mood disorders. It is more likely to cause insomnia than drowsiness. Prescribed for Anxiety and Stress, Major Depressive Disorder... View more |
Prescription only
Zoloft is a brand name for sertraline which is an effective antidepressant with less potential for drowsiness than many other antidepressants. It belongs to the group of medicines called selective... View more |
Related suggestions Depression
Major Depressive Disorder
Panic Disorder
Obsessive Compulsive Disorder
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| More about Prozac (fluoxetine) | More about Zoloft (sertraline) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Prozac has an average rating of 7.2 out of 10 from a total of 1239 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 20% reported a negative effect. |
Zoloft has an average rating of 7.3 out of 10 from a total of 1972 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 18% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Prozac side effects |
View all Zoloft side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Prozac prices |
View all Zoloft prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
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N/A |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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210 hours |
66 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 681 drugs are known to interact with Prozac:
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A total of 673 drugs are known to interact with Zoloft:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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December 29, 1987 |
December 30, 1991 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.