Comparing Pristiq vs Zoloft
| Pristiq | Zoloft |
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| Pristiq (desvenlafaxine) | Zoloft (sertraline) |
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Prescription only
Prescribed for Major Depressive Disorder, Depression. Pristiq may also be used for purposes not listed in this medication guide. |
Prescription only
Zoloft is a brand name for sertraline which is an effective antidepressant with less potential for drowsiness than many other antidepressants. It belongs to the group of medicines called selective... View more |
Related suggestions Depression
Major Depressive Disorder
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| More about Pristiq (desvenlafaxine) | More about Zoloft (sertraline) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Pristiq has an average rating of 6.9 out of 10 from a total of 1126 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 22% reported a negative effect. |
Zoloft has an average rating of 7.3 out of 10 from a total of 1955 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 19% reported a negative effect. |
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| Side Effects | |||||||||||||||||
| Generic Availability | |||||||||||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Pristiq prices |
View all Zoloft prices |
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| Dosage Forms Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
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N/A |
N/A |
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| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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11 hours |
66 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 479 drugs are known to interact with Pristiq:
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A total of 670 drugs are known to interact with Zoloft:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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February 29, 2008 |
December 30, 1991 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.