Skip to main content

Onset Forte Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Onset Forte (acetaminophen / chlorpheniramine / phenylephrine) Benadryl (diphenhydramine) Vicks NyQuil Cold & Flu Nighttime Relief (acetaminophen / dextromethorphan / doxylamine)
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Onset Forte (acetaminophen / chlorpheniramine / phenylephrine) Benadryl (diphenhydramine) Vicks NyQuil Cold & Flu Nighttime Relief (acetaminophen / dextromethorphan / doxylamine)
Prescription and OTC

Prescribed for Cold Symptoms, Sinus Symptoms. Onset Forte may also be used for purposes not listed in this medication guide.

Prescription and OTC

Benadryl is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side effect... View more

Over-the-counter

Prescribed for Cough, Cold Symptoms. Vicks NyQuil Cold & Flu Nighttime Relief may also be used for purposes not listed in this medication guide.

More about Onset Forte (acetaminophen / chlorpheniramine / phenylephrine) More about Benadryl (diphenhydramine) More about Vicks NyQuil Cold & Flu Nighttime Relief (acetaminophen / dextromethorphan / doxylamine)
Ratings & Reviews

Be the first to share your experience with this drug.

Benadryl has an average rating of 7.2 out of 10 from a total of 78 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 18% reported a negative effect.

Vicks NyQuil Cold & Flu Nighttime Relief has an average rating of 2.0 out of 10 from a total of 1 ratings on Drugs.com. 0% of reviewers reported a positive effect, while 100% reported a negative effect.

Review this drug

View all 78 reviews

View all 1 reviews

Drug Class
Side Effects

Onset Forte side effects

Benadryl side effects

Vicks NyQuil Cold & Flu Nighttime Relief side effects
Generic Availability

N/A

N/A

N/A
Pricing and Coupons * Prices are without insurance

We could not find an exact match for this medicine. Try searching the Price Guide directly.
Quantity 24 tablet
Strength 25 mg
Per Unit* $0.42
Cost* $9.99

View all Benadryl prices

We could not find an exact match for this medicine. Try searching the Price Guide directly.

Get free Discount Card

Get free Discount Card

Get free Discount Card

Dosage Forms Available

N/A
  • Oral capsule
  • Oral tablet

N/A
Brand Names
Other acetaminophen / chlorpheniramine / phenylephrine brands include: Allergy Multi-Symptom, Allergy Pain Relief, Allergy Sinus PE Pain Relief, BC Sinus Pain & Congestion, Comtrex Flu Therapy, Comtrex Severe Cold & Sinus, ConRx Allergy Sinus, Contac Cold + Flu (Night Formula), Dristan Cold Multi Symptom Formula, Dryphen, Gendecon, GNP Cold Relief Plus, HEB Allergy, Hybrid CF, Medicidin-D, Norel AD, PX Allergy Sinus PE, Pyrroxate, Relief-PE, Robitussin Peak Cold Nighttime Nasal Relief, Sine-Off Sinus/Cold, Super Strength Sinadrin, Tylenol Allergy Multi-Symptom, Tylenol Plus Children's Cold, Tylenol Sinus Congestion & Pain Nighttime, Tylenol Sinus Congestion and Pain Cool Burst Day Night, XL-3 Cold Medicine View more Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more Other acetaminophen / dextromethorphan / doxylamine brands include: Alka-Seltzer Plus Severe Cold+Cough Night Liquid, Clear Cough PM Multi-Symptom, Contac Cold + Flu (Night) Cooling Relief Liquid, Coricidin HBP Nighttime Multi-Symptom Cold, Delsym Night Time Cough & Cold, Multi Symptom NiteTime, Night Time Multi Symptom Cold/Flu Relief, Robitussin Cold + Flu (Nighttime), Robitussin Peak Cold Nighttime Cold + Flu, Tylenol Cold & Cough Nighttime, Tylenol Cough & Sore Throat Nightime, Vicks Nature Fusion Cold & Flu Nighttime Relief, Vicks NyQuil HBP Cold & Flu View more
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

30 hours

9.3 hours

N/A
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
N
Category N Not classified
B
Category B No proven risk in humans

See the full pregnancy warnings document.
N
Category N Not classified
Drug Interactions

A total of 578 drugs are known to interact with Onset Forte:

  • 44 major drug interactions (163 brand and generic names)
  • 520 moderate drug interactions (2218 brand and generic names)
  • 14 minor drug interactions (53 brand and generic names)

A total of 451 drugs are known to interact with Benadryl:

  • 14 major drug interactions (90 brand and generic names)
  • 435 moderate drug interactions (1680 brand and generic names)
  • 2 minor drug interactions (8 brand and generic names)

A total of 496 drugs are known to interact with Vicks NyQuil Cold & Flu Nighttime Relief:

  • 90 major drug interactions (328 brand and generic names)
  • 389 moderate drug interactions (1562 brand and generic names)
  • 17 minor drug interactions (61 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol can increase the nervous system side effects of chlorpheniramine such as dizziness... View more
  • Ask your doctor before using diphenhydrAMINE together with alcohol. Use alcohol cautiously... View more
  • Alcohol can increase the nervous system side effects of dextromethorphan such as dizziness... View more
Disease Interactions
First Approval Date

N/A

March 04, 1946

N/A
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources

N/A

N/A
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Compare Drugs

To view a report comparing 3 (or more) medications, please sign in or create an account.

Create an account Sign In