Comparing Nitrofurantoin vs Trimethoprim
| Nitrofurantoin | Trimethoprim |
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| Nitrofurantoin | Trimethoprim |
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Prescription only
Nitrofurantoin is an effective antibiotic with a low risk of inducing bacterial resistance that is used specifically to treat urinary tract infections caused by susceptible bacteria. Long-term use... View more |
Prescription only
Prescribed for Urinary Tract Infection, Prevention of Bladder infection, Bladder Infection, Middle Ear Infections, Pneumocystis Pneumonia. Trimethoprim may also be used for purposes not listed in... View more |
Related suggestions Urinary Tract Infection
Bladder Infection
Prevention of Bladder infection (Cystitis Prophylaxis)
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| More about Nitrofurantoin | More about Trimethoprim | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Nitrofurantoin has an average rating of 4.5 out of 10 from a total of 1873 ratings on Drugs.com. 30% of reviewers reported a positive effect, while 52% reported a negative effect. |
Trimethoprim has an average rating of 3.0 out of 10 from a total of 195 ratings on Drugs.com. 13% of reviewers reported a positive effect, while 72% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Nitrofurantoin prices |
View all Trimethoprim prices |
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| Dosage Forms Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Furadantin, Macrobid, Macrodantin | Primsol | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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1 hour |
14 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 199 drugs are known to interact with Nitrofurantoin:
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A total of 132 drugs are known to interact with Trimethoprim:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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February 06, 1953 |
May 30, 1980 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.