Comparing Nitrofurantoin vs Sulfamethoxazole / Trimethoprim
| Nitrofurantoin | Sulfamethoxazole / trimethoprim |
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| Nitrofurantoin | Sulfamethoxazole / trimethoprim |
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Prescription only
Nitrofurantoin is an effective antibiotic with a low risk of inducing bacterial resistance that is used specifically to treat urinary tract infections caused by susceptible bacteria. Long-term use... View more |
Prescription only
Sulfamethoxazole/trimethoprim is an effective combination antibiotic; however, it may not be suitable for those with kidney or liver disease or folate deficiency. The risk of side effects may be... View more |
Related suggestions Urinary Tract Infection
Prevention of Bladder infection (Cystitis Prophylaxis)
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| More about Nitrofurantoin | More about Sulfamethoxazole / trimethoprim | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Nitrofurantoin has an average rating of 4.5 out of 10 from a total of 1878 ratings on Drugs.com. 29% of reviewers reported a positive effect, while 52% reported a negative effect. |
Sulfamethoxazole / trimethoprim has an average rating of 4.9 out of 10 from a total of 1720 ratings on Drugs.com. 34% of reviewers reported a positive effect, while 47% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Nitrofurantoin side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Nitrofurantoin prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Furadantin, Macrobid, Macrodantin | Bactrim, Bactrim DS, Bactrim IV, Bactrim Pediatric, Bethaprim, Bethaprim Pediatric, Co-trimoxazole, Septra, Septra DS, SMZ-TMP DS, Sulfatrim Pediatric View more | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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1 hour |
14 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category D
Positive evidence of risk
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 219 drugs are known to interact with Nitrofurantoin:
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A total of 450 drugs are known to interact with Sulfamethoxazole / trimethoprim:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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February 06, 1953 |
July 30, 1973 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
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| Related Treatment Guide | |||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.