Naproxen Alternatives Compared
| Naproxen | Cimzia | Methotrexate |
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| Naproxen | Cimzia (certolizumab) | Methotrexate |
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Prescription and OTC
Naproxen is effective for the short-term relief of pain and inflammation associated with arthritis, gout, menstruation, and tendonitis; however, like other NSAIDs, it has the potential to adversely... View more |
Prescription only
Prescribed for Ankylosing Spondylitis, Crohn's Disease, Crohn's Disease - Active, Crohn's Disease - Maintenance, Non-Radiographic Axial Spondyloarthritis, Plaque Psoriasis, Psoriasis, Psoriatic... View more |
Prescription only
Methotrexate may be considered for the treatment of psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), mycosis fungoides, and certain cancers, such as ALL or... View more |
Related suggestions Rheumatoid Arthritis
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| More about Naproxen | More about Cimzia (certolizumab) | More about Methotrexate | ||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||
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Naproxen has an average rating of 6.9 out of 10 from a total of 681 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 24% reported a negative effect. |
Cimzia has an average rating of 6.7 out of 10 from a total of 90 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 21% reported a negative effect. |
Methotrexate has an average rating of 6.6 out of 10 from a total of 334 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 23% reported a negative effect. |
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| Drug Class | ||||||||||||||||||
| Side Effects | ||||||||||||||||||
| Generic Availability | ||||||||||||||||||
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Lower cost generic |
N/A |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
View all Naproxen prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Methotrexate prices |
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| Dosage Forms Available | ||||||||||||||||||
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| Brand Names | ||||||||||||||||||
| Aflaxen, Aleve, Aleve Back and Muscle Pain, All Day Pain Relief, All Day Relief, Anaprox-DS, Comfort Pac with Naproxen, EC-Naprosyn, Flanax Pain Reliever, Midol Extended Relief, Naprelan, Naprosyn, Naproxen Sodium DS, Pamprin All Day Relief View more |
N/A |
Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||
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18 hours |
336 hours |
15 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||
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A total of 432 drugs are known to interact with Naproxen:
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A total of 427 drugs are known to interact with Cimzia:
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A total of 708 drugs are known to interact with Methotrexate:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||
| First Approval Date | ||||||||||||||||||
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March 11, 1976 |
April 22, 2008 |
December 07, 1953 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||
| Patient resources | ||||||||||||||||||
| Professional Resources | ||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.