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Multi Symptom Cold Relief Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Multi Symptom Cold Relief (acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine) Benadryl (diphenhydramine) Vicks NyQuil Cold & Flu Nighttime Relief (acetaminophen / dextromethorphan / doxylamine)
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Multi Symptom Cold Relief (acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine) Benadryl (diphenhydramine) Vicks NyQuil Cold & Flu Nighttime Relief (acetaminophen / dextromethorphan / doxylamine)
Over-the-counter

Prescribed for Cold Symptoms, Rhinorrhea, Cough, Cough and Nasal Congestion, Nasal Congestion, Sinus Symptoms. Multi Symptom Cold Relief may also be used for purposes not listed in this medication guide. View more

Prescription and OTC

Benadryl is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side effect... View more

Over-the-counter

Prescribed for Cough, Cold Symptoms. Vicks NyQuil Cold & Flu Nighttime Relief may also be used for purposes not listed in this medication guide.

More about Benadryl (diphenhydramine) More about Vicks NyQuil Cold & Flu Nighttime Relief (acetaminophen / dextromethorphan / doxylamine)
Ratings & Reviews

Be the first to share your experience with this drug.

Benadryl has an average rating of 7.2 out of 10 from a total of 78 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 18% reported a negative effect.

Vicks NyQuil Cold & Flu Nighttime Relief has an average rating of 2.0 out of 10 from a total of 1 ratings on Drugs.com. 0% of reviewers reported a positive effect, while 100% reported a negative effect.

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Drug Class
Side Effects

Multi Symptom Cold Relief side effects

Benadryl side effects

Vicks NyQuil Cold & Flu Nighttime Relief side effects
Generic Availability

N/A

N/A

N/A
Pricing and Coupons * Prices are without insurance

We could not find an exact match for this medicine. Try searching the Price Guide directly.
Quantity 24 tablet
Strength 25 mg
Per Unit* $0.42
Cost* $9.99

View all Benadryl prices

We could not find an exact match for this medicine. Try searching the Price Guide directly.

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Dosage Forms Available

N/A
  • Oral capsule
  • Oral tablet

N/A
Brand Names
Other acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine brands include: Alka-Seltzer Plus Maximum Strength Cold & Cough, Alka-Seltzer Plus Maximum Strength Cold & Cough Liquid Gels, Alka-Seltzer Plus Maximum Strength Sinus Congestion & Pain PowerFast Fizz, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Alka-Seltzer Plus Severe Cold & Flu PowerFast Fizz, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Codral Cold and Flu + Cough Day and Night, Cold Multi-Symptom (Nighttime), Comtrex Cold & Cough Day Night, Comtrex Nighttime Cold & Cough, Giltuss Children's Multi-Symptom Cold & Flu, Giltuss Multi-Symptom Cold & Flu, Multi Symptom Cold (Night Formula), PediaCare Flu Plus Acetaminophen, PediaCare Multi-Symptom Cold Plus Acetaminophen, Theraflu Nighttime Severe Cold & Cough Caplets, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Triaminic Multi-Symptom Fever & Cold, Tylenol Children’s Cold + Flu, Tylenol Cold Head Congestion Day and Night, Tylenol Cold Head Congestion Nighttime, Tylenol Cold Multi-Symptom Nighttime, XL-3 Xtra Cold and Cough View more Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more Other acetaminophen / dextromethorphan / doxylamine brands include: Alka-Seltzer Plus Severe Cold+Cough Night Liquid, Clear Cough PM Multi-Symptom, Contac Cold + Flu (Night) Cooling Relief Liquid, Coricidin HBP Nighttime Multi-Symptom Cold, Delsym Night Time Cough & Cold, Multi Symptom NiteTime, Night Time Multi Symptom Cold/Flu Relief, Robitussin Cold + Flu (Nighttime), Robitussin Peak Cold Nighttime Cold + Flu, Tylenol Cold & Cough Nighttime, Tylenol Cough & Sore Throat Nightime, Vicks Nature Fusion Cold & Flu Nighttime Relief, Vicks NyQuil HBP Cold & Flu View more
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

30 hours

9.3 hours

N/A
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
N
Category N Not classified

See the full pregnancy warnings document.
B
Category B No proven risk in humans

See the full pregnancy warnings document.
N
Category N Not classified
Drug Interactions

A total of 644 drugs are known to interact with Multi Symptom Cold Relief:

  • 98 major drug interactions (347 brand and generic names)
  • 531 moderate drug interactions (2173 brand and generic names)
  • 15 minor drug interactions (52 brand and generic names)

A total of 451 drugs are known to interact with Benadryl:

  • 14 major drug interactions (90 brand and generic names)
  • 435 moderate drug interactions (1682 brand and generic names)
  • 2 minor drug interactions (8 brand and generic names)

A total of 497 drugs are known to interact with Vicks NyQuil Cold & Flu Nighttime Relief:

  • 90 major drug interactions (329 brand and generic names)
  • 390 moderate drug interactions (1567 brand and generic names)
  • 17 minor drug interactions (61 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol can increase the nervous system side effects of chlorpheniramine such as dizziness... View more
  • Ask your doctor before using diphenhydrAMINE together with alcohol. Use alcohol cautiously... View more
  • Alcohol can increase the nervous system side effects of dextromethorphan such as dizziness... View more
Disease Interactions
First Approval Date

N/A

March 04, 1946

N/A
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources

N/A
Professional Resources

N/A

N/A
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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