Comparing Methotrexate vs Sulfasalazine
| Methotrexate | Sulfasalazine |
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| Methotrexate | Sulfasalazine |
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Prescription only
Methotrexate may be considered for the treatment of psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), mycosis fungoides, and certain cancers, such as ALL or... View more |
Prescription only
Prescribed for Alopecia, Crohn's Disease, Crohn's Disease - Maintenance, Juvenile Rheumatoid Arthritis, Lymphocytic Colitis, Inflammatory Bowel Disease, Crohn's Disease - Active, Psoriatic Arthritis... View more |
Related suggestions Rheumatoid Arthritis
Uveitis
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| More about Methotrexate | More about Sulfasalazine | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Methotrexate has an average rating of 6.5 out of 10 from a total of 335 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 24% reported a negative effect. |
Sulfasalazine has an average rating of 6.0 out of 10 from a total of 198 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 33% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Methotrexate side effects |
View all Sulfasalazine side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Methotrexate prices |
View all Sulfasalazine prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep | Azulfidine, Azulfidine EN-tabs | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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15 hours |
10 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 716 drugs are known to interact with Methotrexate:
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A total of 268 drugs are known to interact with Sulfasalazine:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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December 07, 1953 |
June 20, 1950 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.