Comparing Losartan vs Sildenafil

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Losartan

Sildenafil

Prescription only

Losartan works on a hormone called angiotensin II to lower blood pressure and may also improve kidney function in some people. People being initiated on losartan should be adequately rehydrated and... View more

Prescription only

Sildenafil is used to treat erectile dysfunction (ED) and to reduce blood pressure in pulmonary arterial hypertension (PAH). It is taken when needed for ED and daily for PAH. A headache, stomach... View more

More about Losartan

More about Sildenafil

Ratings & Reviews

Losartan has an average rating of 4.5 out of 10 from a total of 578 ratings on Drugs.com. 26% of reviewers reported a positive effect, while 48% reported a negative effect.

Sildenafil has an average rating of 8.3 out of 10 from a total of 499 ratings on Drugs.com. 79% of reviewers reported a positive effect, while 12% reported a negative effect.

View all 578 reviews

View all 499 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Dizziness (14.9%)
Anxiety (14.7%)
Tiredness (12.6%)
Headaches (12.1%)
Cough (11.9%)
Pain (10.9%)
Insomnia (8.3%)

View all Losartan side effects

Headaches (14.8%)
Flushing (5.2%)
Runny nose (3.6%)
Stuffy nose (1.4%)
Tiredness (1.4%)
Insomnia (1.2%)
Anxiety (1.0%)

View all Sildenafil side effects

Drug Class

Angiotensin receptor blockers

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	50 each
Strength	50 mg
Per unit^*	$0.64
Cost^*	$32.05

View all Losartan prices

Quantity	2 tablet
Strength	100 mg
Per unit^*	$5.07 - $14.31
Cost^*	$10.13 - $28.62

View all Sildenafil prices

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Dosage Forms

Oral tablet

Intravenous solution
Oral powder for reconstitution
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

4.4 hours

4 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category D Positive evidence of risk

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Drug Interactions

A total of 324 drugs are known to interact with Losartan:

32 major drug interactions (165 brand and generic names)
276 moderate drug interactions (1331 brand and generic names)
16 minor drug interactions (39 brand and generic names)

A total of 367 drugs are known to interact with Sildenafil:

101 major drug interactions (359 brand and generic names)
260 moderate drug interactions (790 brand and generic names)
6 minor drug interactions (46 brand and generic names)

Alcohol/Food/Lifestyle Interactions

If you are taking losartan you should avoid potassium-containing salt substitutes or... View more
Losartan and alcohol may have additive effects in lowering your blood pressure. You may experience... View more

If you are receiving therapy with sildenafil you should avoid the regular consumption of large... View more
Sildenafil can lower blood pressure, and combining it with alcohol may further increase this... View more

Disease Interactions

First Approval Date

April 14, 1995

March 27, 1998

WADA Class View classifications

N/A

More Information

Patient Resources

Losartan uses

Sildenafil uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Losartan vs Sildenafil

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