Lisdexamfetamine Alternatives Compared
Lisdexamfetamine | Xywav | Provigil |
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Lisdexamfetamine | Xywav (calcium oxybate / magnesium oxybate / potassium oxybate / sodium oxybate) | Provigil (modafinil) |
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Prescription only
Lisdexamfetamine is a stimulant that may be used for the treatment of ADHD and BED; however, its use is limited by its risk of dependence, withdrawal syndrome, and potential for serious cardiac... View more |
Prescription only
Xywav may be used to treat idiopathic hypersomnia in adults or narcolepsy in adults and children aged 7 and older. It contains 92% less sodium than sodium oxybate (Xyrem) because it is made up of a... View more |
Prescription only
Prescribed for Shift Work Sleep Disorder, Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome. Provigil may also be used for purposes not listed in this medication guide. |
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More about Lisdexamfetamine | More about Xywav (calcium oxybate / magnesium oxybate / potassium oxybate / sodium oxybate) | More about Provigil (modafinil) | ||||||||||||||||||||||||
Ratings & Reviews | ||||||||||||||||||||||||||
Lisdexamfetamine has an average rating of 7.5 out of 10 from a total of 1069 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 16% reported a negative effect. |
Xywav has an average rating of 8.0 out of 10 from a total of 14 ratings on Drugs.com. 79% of reviewers reported a positive effect, while 14% reported a negative effect. |
Provigil has an average rating of 7.5 out of 10 from a total of 166 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 16% reported a negative effect. |
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Drug Class | ||||||||||||||||||||||||||
Side Effects | ||||||||||||||||||||||||||
See also: lisdexamfetamine side effects in more detail. |
See also: Xywav side effects in more detail. |
See also: Provigil side effects in more detail. |
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Generic Availability | ||||||||||||||||||||||||||
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all lisdexamfetamine prices |
View all Xywav prices |
View all Provigil prices |
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Dosage Forms Available | ||||||||||||||||||||||||||
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Brand Names | ||||||||||||||||||||||||||
Vyvanse |
N/A |
N/A |
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Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
1 hour |
0.66 hours |
15 hours |
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CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
Moderate abuse potential
Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |
Some potential for abuse
Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. |
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Pregnancy Category | ||||||||||||||||||||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | ||||||||||||||||||||||||||
A total of 370 drugs are known to interact with lisdexamfetamine:
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A total of 343 drugs are known to interact with Xywav:
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A total of 507 drugs are known to interact with Provigil:
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Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions | ||||||||||||||||||||||||||
First Approval Date | ||||||||||||||||||||||||||
February 23, 2007 |
July 21, 2020 |
December 24, 1998 |
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WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
N/A |
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More Information | ||||||||||||||||||||||||||
Patient resources | ||||||||||||||||||||||||||
Professional Resources | ||||||||||||||||||||||||||
Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.