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Comparing Lexapro vs Wellbutrin XL

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Lexapro (escitalopram) Wellbutrin XL (bupropion)
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Lexapro (escitalopram) Wellbutrin XL (bupropion)
Prescription only

Lexapro is an effective antidepressant that may have less potential for adverse effects than other SSRI antidepressants. Prescribed for Anxiety, Major Depressive Disorder, Generalized Anxiety... View more

Prescription only

Prescribed for Major Depressive Disorder, Depression, Seasonal Affective Disorder. Wellbutrin XL may also be used for purposes not listed in this medication guide.

More about Lexapro (escitalopram) More about Wellbutrin XL (bupropion)
Ratings & Reviews

Lexapro has an average rating of 7.6 out of 10 from a total of 2376 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 15% reported a negative effect.

Wellbutrin XL has an average rating of 7.5 out of 10 from a total of 492 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 16% reported a negative effect.

View all 2376 reviews

View all 492 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Lexapro side effects

View all Wellbutrin XL side effects
Drug Class
Generic Availability

Lower cost generic approved

Lower cost generic approved
Pricing and Coupons * Prices are without insurance
Quantity 100 tablet
Strength 10 mg
Per unit* $16.51
Cost* $1,651.38

View all Lexapro prices

Quantity 30 tablet, extended release
Strength 150 mg/24 hours
Per unit* $78.44
Cost* $2,353.09

View all Wellbutrin XL prices

Get free Discount Card

Get free Discount Card

Dosage Forms
  • Oral solution
  • Oral tablet
  • Oral tablet, extended release
Brand Names

N/A

 Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

32 hours

30 hours
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 705 drugs are known to interact with Lexapro:

  • 265 major drug interactions (946 brand and generic names)
  • 393 moderate drug interactions (1776 brand and generic names)
  • 47 minor drug interactions (146 brand and generic names)

A total of 527 drugs are known to interact with Wellbutrin XL:

  • 217 major drug interactions (949 brand and generic names)
  • 305 moderate drug interactions (1377 brand and generic names)
  • 5 minor drug interactions (16 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol can increase the nervous system side effects of escitalopram such as dizziness, drowsiness... View more
  • Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more
Disease Interactions
First Approval Date

August 14, 2002

August 28, 2003
WADA Class View classifications

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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