Comparing Isotretinoin vs Methotrexate
Isotretinoin | Methotrexate |
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Isotretinoin | Methotrexate |
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Prescription only
Prescribed for Rosacea, Acne, Granuloma Annulare, Acute Nonlymphocytic Leukemia, Melanoma - Metastatic, Pityriasis rubra pilaris. isotretinoin may also be used for purposes not listed in this medication guide. View more |
Prescription only
Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Related suggestions Pityriasis rubra pilaris
Acute Nonlymphocytic Leukemia
Popular comparisons
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More about Isotretinoin | More about Methotrexate | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Isotretinoin has an average rating of 8.0 out of 10 from a total of 1055 ratings on Drugs.com. 74% of reviewers reported a positive effect, while 13% reported a negative effect. |
Methotrexate has an average rating of 6.6 out of 10 from a total of 330 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 23% reported a negative effect. |
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Drug Class | |||||||||||||||||
Side Effects | |||||||||||||||||
See also: isotretinoin side effects in more detail. |
See also: methotrexate side effects in more detail. |
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Generic Availability | |||||||||||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all isotretinoin prices |
View all methotrexate prices |
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Dosage Forms Available | |||||||||||||||||
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Brand Names | |||||||||||||||||
Absorica, Absorica LD, Accutane, Amnesteem, Claravis, Myorisan, Sotret, Zenatane | Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep | ||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
32 hours |
15 hours |
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CSA Schedule ** View glossary of terms | |||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||||||||||
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 131 drugs are known to interact with isotretinoin:
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A total of 701 drugs are known to interact with methotrexate:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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Disease Interactions | |||||||||||||||||
First Approval Date | |||||||||||||||||
May 07, 1982 |
December 07, 1953 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
N/A |
N/A |
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More Information | |||||||||||||||||
Patient resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.