Comparing Isotretinoin vs Methotrexate
| Isotretinoin | Methotrexate |
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| Isotretinoin | Methotrexate |
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Prescription only
Prescribed for Acne, Rosacea, Acute Nonlymphocytic Leukemia, Granuloma Annulare, Melanoma - Metastatic, Pityriasis rubra pilaris. Isotretinoin may also be used for purposes not listed in this medication guide. View more |
Prescription only
Methotrexate may be considered for the treatment of psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), mycosis fungoides, and certain cancers, such as ALL or... View more |
Related suggestions Pityriasis rubra pilaris
Acute Nonlymphocytic Leukemia
Popular comparisons
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| More about Isotretinoin | More about Methotrexate | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Isotretinoin has an average rating of 8.0 out of 10 from a total of 1059 ratings on Drugs.com. 74% of reviewers reported a positive effect, while 13% reported a negative effect. |
Methotrexate has an average rating of 6.6 out of 10 from a total of 335 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 23% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Isotretinoin prices |
View all Methotrexate prices |
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| Dosage Forms Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Absorica, Absorica LD, Accutane, Amnesteem, Claravis, Myorisan, Sotret, Zenatane | Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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32 hours |
15 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 137 drugs are known to interact with Isotretinoin:
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A total of 709 drugs are known to interact with Methotrexate:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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May 07, 1982 |
December 07, 1953 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.