Hydrochlorothiazide Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Hydrochlorothiazide	Lisinopril	Amlodipine	Enter another drug to compare

Hydrochlorothiazide

Lisinopril

Amlodipine

Prescription only

Hydrochlorothiazide (HCTZ) may be used to relieve edema (fluid retention) and to lower high blood pressure. A headache, dizziness on standing, dehydration, skin reactions, and depletion of... View more

Prescription only

Lisinopril can be used to treat high blood pressure and heart failure, and to increase survival following a heart attack. However, lisinopril may cause a persistent, dry, hacking cough which may... View more

Prescription only

Amlodipine is a heart medication that may be used for the treatment of angina or to lower blood pressure but it can cause edema in the ankles or feet. Prescribed for Raynaud's Syndrome, High Blood... View more

More about Hydrochlorothiazide

More about Lisinopril

More about Amlodipine

Ratings & Reviews

Hydrochlorothiazide has an average rating of 5.2 out of 10 from a total of 185 ratings on Drugs.com. 35% of reviewers reported a positive effect, while 38% reported a negative effect.

Lisinopril has an average rating of 5.0 out of 10 from a total of 626 ratings on Drugs.com. 34% of reviewers reported a positive effect, while 44% reported a negative effect.

Amlodipine has an average rating of 4.4 out of 10 from a total of 838 ratings on Drugs.com. 28% of reviewers reported a positive effect, while 53% reported a negative effect.

View all 185 reviews

View all 626 reviews

View all 838 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Dizziness (13.0%)
Tiredness (8.6%)
Headaches (8.1%)
Swelling (8.1%)
Dry mouth (7.0%)
Cramps (6.5%)
Fatigue (6.5%)

View all Hydrochlorothiazide side effects

Cough (28.8%)
Dizziness (12.1%)
Headaches (10.2%)
Tiredness (7.5%)
Swelling (6.7%)
Pain (5.9%)
Fatigue (5.1%)

View all Lisinopril side effects

Swelling (14.8%)
Anxiety (13.2%)
Headaches (13.1%)
Dizziness (12.3%)
Tiredness (10.5%)
Pain (9.7%)
Fatigue (9.5%)

View all Amlodipine side effects

Drug Class

Thiazide diuretics

Angiotensin Converting Enzyme Inhibitors

Calcium channel blockers

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	7 tablet
Strength	25 mg
Per unit^*	$1.35
Cost^*	$9.44

View all Hydrochlorothiazide prices

Quantity	100 each
Strength	20 mg
Per unit^*	$0.15 - $0.20
Cost^*	$14.97 - $19.75

View all Lisinopril prices

Quantity	100 each
Strength	10 mg
Per unit^*	$0.22 - $0.76
Cost^*	$22.45 - $76.44

View all Amlodipine prices

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Dosage Forms

Oral capsule
Oral tablet

Oral tablet

Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

12 hours

16.4 hours

35 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category B No proven risk in humans

See the full pregnancy warnings document.

Category D Positive evidence of risk

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 472 drugs are known to interact with Hydrochlorothiazide:

16 major drug interactions (47 brand and generic names)
423 moderate drug interactions (2569 brand and generic names)
33 minor drug interactions (137 brand and generic names)

A total of 403 drugs are known to interact with Lisinopril:

44 major drug interactions (192 brand and generic names)
329 moderate drug interactions (1551 brand and generic names)
30 minor drug interactions (231 brand and generic names)

A total of 538 drugs are known to interact with Amlodipine:

23 major drug interactions (72 brand and generic names)
475 moderate drug interactions (3080 brand and generic names)
39 minor drug interactions (106 brand and generic names)

Alcohol/Food/Lifestyle Interactions

HydroCHLOROthiazide and alcohol may have additive effects in lowering your blood pressure. You may... View more

It is recommended that if you are taking lisinopril you should be advised to avoid moderately high... View more
Lisinopril and alcohol may have additive effects in lowering your blood pressure. You may... View more

AmLODIPine and alcohol may have additive effects in lowering your blood pressure. You may... View more

Disease Interactions

First Approval Date

February 12, 1959

December 29, 1987

July 31, 1992

WADA Class View classifications

S5 - Diuretics and Other Masking Agents

N/A

More Information

Patient Resources

Hydrochlorothiazide uses

Lisinopril uses

Amlodipine uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Hydrochlorothiazide Alternatives Compared

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