Glyburide Alternatives Compared
| Glyburide | Rybelsus (semaglutide) | Semaglutide |
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| Glyburide | Rybelsus (semaglutide) | Semaglutide |
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Prescription only
Prescribed for Type 2 Diabetes. Glyburide may also be used for purposes not listed in this medication guide. |
Prescription only
Rybelsus (semaglutide) is an oral medicine that can be used as a first-line medication to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It works by mimicking the... View more |
Prescription only
Semaglutide lowers blood sugar levels by mimicking the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It is taken... View more |
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| More about Glyburide | More about Rybelsus (semaglutide) | More about Semaglutide | ||||||||
| Ratings & Reviews | ||||||||||
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Glyburide has an average rating of 7.2 out of 10 from a total of 9 ratings on Drugs.com. 78% of reviewers reported a positive effect, while 22% reported a negative effect. |
Rybelsus has an average rating of 6.4 out of 10 from a total of 266 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 25% reported a negative effect. |
Semaglutide has an average rating of 6.9 out of 10 from a total of 2406 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 21% reported a negative effect. |
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| Drug Class | ||||||||||
| Side Effects | ||||||||||
| Generic Availability | ||||||||||
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Lower cost generic |
N/A |
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| Pricing and Coupons * Prices are without insurance | ||||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Rybelsus prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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| Dosage Forms Available | ||||||||||
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N/A |
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| Brand Names | ||||||||||
| DiaBeta, Glycron, Glynase, Glynase PresTab | Other semaglutide brands include: Ozempic, Wegovy | Ozempic, Rybelsus, Wegovy | ||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||
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16 hours |
168 hours |
168 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||
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A total of 500 drugs are known to interact with Glyburide:
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A total of 267 drugs are known to interact with Rybelsus:
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A total of 267 drugs are known to interact with Semaglutide:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||
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| Disease Interactions | ||||||||||
| First Approval Date | ||||||||||
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May 01, 1984 |
September 20, 2019 |
December 05, 2017 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||
| Patient resources | ||||||||||
| Professional Resources | ||||||||||
| Related Treatment Guide | ||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.