Fetzima Alternatives Compared
| Fetzima (levomilnacipran) | Trintellix (vortioxetine) | Rexulti (brexpiprazole) |
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| Fetzima (levomilnacipran) | Trintellix (vortioxetine) | Rexulti (brexpiprazole) |
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Prescription only
Prescribed for Major Depressive Disorder, Depression. Fetzima may also be used for purposes not listed in this medication guide. |
Prescription only
Trintellix may be used to treat depression in adults. It is different from other antidepressants currently on the market because it directly affects serotonin receptors as well as inhibits serotonin... View more |
Prescription only
Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression, or used to relieve agitation associated with dementia in Alzheimer's disease. Most people... View more |
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| More about Fetzima (levomilnacipran) | More about Trintellix (vortioxetine) | More about Rexulti (brexpiprazole) | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Fetzima has an average rating of 5.0 out of 10 from a total of 198 ratings on Drugs.com. 36% of reviewers reported a positive effect, while 44% reported a negative effect. |
Trintellix has an average rating of 6.0 out of 10 from a total of 1125 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 33% reported a negative effect. |
Rexulti has an average rating of 6.6 out of 10 from a total of 478 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 26% reported a negative effect. |
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| Generic Availability | ||||||||||||||||||||||||||
| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Fetzima prices |
View all Trintellix prices |
View all Rexulti prices |
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| Dosage Forms Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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12 hours |
66 hours |
91 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 371 drugs are known to interact with Fetzima:
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A total of 352 drugs are known to interact with Trintellix:
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A total of 592 drugs are known to interact with Rexulti:
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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July 25, 2013 |
September 30, 2013 |
July 10, 2015 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.