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Fetzima Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Fetzima (levomilnacipran) Rexulti (brexpiprazole) Wellbutrin XL (bupropion)
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Fetzima (levomilnacipran) Rexulti (brexpiprazole) Wellbutrin XL (bupropion)
Prescription only

Prescribed for Major Depressive Disorder, Depression. Fetzima may also be used for purposes not listed in this medication guide.

Prescription only

Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression, or used to relieve agitation associated with dementia in Alzheimer's disease. Most people... View more

Prescription only

Prescribed for Major Depressive Disorder, Depression, Seasonal Affective Disorder. Wellbutrin XL may also be used for purposes not listed in this medication guide.

Related suggestions
More about Fetzima (levomilnacipran) More about Rexulti (brexpiprazole) More about Wellbutrin XL (bupropion)
Ratings & Reviews

Fetzima has an average rating of 5.0 out of 10 from a total of 198 ratings on Drugs.com. 36% of reviewers reported a positive effect, while 44% reported a negative effect.

Rexulti has an average rating of 6.6 out of 10 from a total of 487 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 26% reported a negative effect.

Wellbutrin XL has an average rating of 7.5 out of 10 from a total of 492 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 16% reported a negative effect.

View all 198 reviews

View all 487 reviews

View all 492 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Fetzima side effects

View all Rexulti side effects

View all Wellbutrin XL side effects
Drug Class
Generic Availability

No lower cost generic approved

Lower cost generic approved

Lower cost generic approved
Pricing and Coupons * Prices are without insurance
Quantity 28 capsule, extended release
Strength 20 mg-40 mg
Per unit* $18.65
Cost* $522.18

View all Fetzima prices

Quantity 30 tablet
Strength 0.25 mg
Per unit* $53.05
Cost* $1,591.63

View all Rexulti prices

Quantity 30 tablet, extended release
Strength 150 mg/24 hours
Per unit* $76.69
Cost* $2,300.72

View all Wellbutrin XL prices

Get free Discount Card

Get free Discount Card

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Dosage Forms
  • Oral capsule, extended release
  • Oral tablet
  • Oral tablet, extended release
Brand Names

N/A

N/A

 Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

12 hours

91 hours

30 hours
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 372 drugs are known to interact with Fetzima:

  • 115 major drug interactions (480 brand and generic names)
  • 256 moderate drug interactions (1142 brand and generic names)
  • 1 minor drug interactions (3 brand and generic names)

A total of 597 drugs are known to interact with Rexulti:

  • 136 major drug interactions (610 brand and generic names)
  • 459 moderate drug interactions (1710 brand and generic names)
  • 2 minor drug interactions (7 brand and generic names)

A total of 526 drugs are known to interact with Wellbutrin XL:

  • 216 major drug interactions (946 brand and generic names)
  • 305 moderate drug interactions (1377 brand and generic names)
  • 5 minor drug interactions (16 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol can increase the nervous system side effects of levomilnacipran such as dizziness... View more
  • Alcohol can increase the nervous system side effects of brexpiprazole such as dizziness... View more
  • Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more
Disease Interactions
First Approval Date

July 25, 2013

July 10, 2015

August 28, 2003
WADA Class View classifications

N/A

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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