Comparing Estradiol / Norethindrone vs Progesterone
| Estradiol / norethindrone | Progesterone |
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| Estradiol / norethindrone | Progesterone |
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Prescription only
Prescribed for Atrophic Vaginitis, Postmenopausal Symptoms, Atrophic Urethritis, Hypoestrogenism. Estradiol / norethindrone may also be used for purposes not listed in this medication guide. |
Prescription and OTC
Progesterone is a hormone that is used to treat conditions associated with ovulation, fertility, menstruation, menopause, or abnormal uterine bleeding. It may be used in gender-affirming therapy to... View more |
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| More about Estradiol / norethindrone | More about Progesterone | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Estradiol / norethindrone has an average rating of 6.5 out of 10 from a total of 97 ratings on Drugs.com. 58% of reviewers reported a positive effect, while 27% reported a negative effect. |
Progesterone has an average rating of 6.5 out of 10 from a total of 78 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 21% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
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View all Progesterone side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Estradiol / norethindrone prices |
View all Progesterone prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Activella, Amabelz, CombiPatch, Ena, Etyqa, Lopreeza, Mimvey, Mimvey Lo | Crinone, Cyclogest, Endometrin, First Progesterone MC10, First Progesterone MC5, Gestone, Milprosa, Prometrium | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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14 hours |
1 hour |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category B
No proven risk in humans
Oral Formulations
Category N
Not classified
Excluding Oral Formulations See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 434 drugs are known to interact with Estradiol / norethindrone:
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A total of 211 drugs are known to interact with Progesterone:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
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| First Approval Date | |||||||||||||||||
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November 18, 1998 |
November 01, 1974 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.