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Estradiol / norethindrone and Anxiety: What Users Say

Brand names: CombiPatch, Activella, Amabelz, Mimvey, Ena, Etyqa, Lopreeza, Mimvey Lo

Anxiety: mentioned by 10 users (10.3%)

Based on user experiences from 97 Estradiol / norethindrone reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

hot flashes 17.5%
bleeding 12.4%
anxiety 10.3%
insomnia 9.3%
cramps 8.2%
night sweats 8.2%
bloating 6.2%
mood swings 6.2%
hair loss 5.2%
spotting 5.2%

Reviews for Estradiol / norethindrone

Commonly mentioned side effects
  • Lil...
  • Taken for less than 1 month
  • October 23, 2024

For Postmenopausal Symptoms "I’ve been on CombiPatch for 3 weeks. I got it in May 2024 but only had the courage to start in October 2024. I had explant surgery mid-May, so I decided to wait a month or so. Then I got cold feet. In September, my symptoms of menopause were hard to ignore. Anxiety and despair were the worst part for me, and I wasn’t even sure anymore if my hot flashes were causing the despair or if the despair was causing the hot flashes because they always came in pairs. Either way, I knew it wasn’t normal, so I put the first patch on. The first night, and until last night, I was awake 2 to 4 times every night, and the hot flashes joined me every time. I almost stopped. The 4th week now, and my first full night of sleep with no hot flashes was last night. I did go to sleep at midnight, which was 2 hours late for me, but I woke up at 8:30, so it’s great. I did notice some more energy, and my husband attested that my mood is much better. Will I renew my prescription? Not sure. Still afraid of reports of breast cancer."

8 / 10
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7 Report
  • Mer...
  • Taken for 1 to 6 months
  • February 16, 2019

For Postmenopausal Symptoms "I was experiencing anxiety attacks, mood swings, strange electrical shocking sensations, and having trouble sleeping more than 2 or 3 hours at a time, even when I was exhausted. This is a pricey fix, but it immediately took care of my symptoms, but I'm having light periods occasionally. If I forget to change the sticker, those symptoms return. I'm on the low dose. I'm so thankful for this drug, while I am not a fan of drugs in general, this has definitely helped my quality of life."

10 / 10
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36 Report
  • Slo...
  • Taken for 6 months to 1 year
  • December 7, 2022

For Postmenopausal Symptoms "I’m 48, been on CombiPatch for almost a year. For the first 6 months, I was on the low dose - which was great and alleviated many symptoms: hot flashes, sleeplessness, anxiety, and weight gain in the midsection. I changed to the higher dose in May and felt great, so I thought I could go back down to the lower dose in Sept., but that was a mistake. I just went back to the higher dose again and I’ll see how it goes in the winter. I did develop an allergic reaction to the adhesive, but my dermatologist prescribed cortisone cream, I apply a bit to my skin and let it dry, and the patch can be tolerated! Also, I do follow a lot of the Galveston Diet protocols, and it helps immensely. I feel like I do a lot just to feel like myself, but it’s worth it."

9 / 10
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17 Report
  • Hop...
  • Taken for less than 1 month
  • December 30, 2019

For Postmenopausal Symptoms "I have been using the CombiPatch for a week now for menopausal problems. I have had no side effects thus far. I did not have hot flashes, but had night sweats and severe moodiness. I was not a nice person all the time! I also experienced severe anxiety. This patch is very much helping me relax. I coupled the patch with Prozac. I just want to get back to normal!"

9 / 10
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30 Report
  • Hot...
  • Taken for 1 to 6 months
  • May 30, 2018

For Postmenopausal Symptoms "I am 54 years old and have had no period for about 2 years. My hot flashes were unbearable, also night sweats and trouble sleeping, anxiety - lots of issues. The CombiPatch has helped tremendously and in a short period of time. Feel like I have my life back to enjoy."

10 / 10
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34 Report

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  • Mar...
  • Taken for 6 months to 1 year
  • June 4, 2019

For Postmenopausal Symptoms "Started the patch one year ago, it took away my symptoms almost immediately: hot flashes, sleepless nights, electrical shock feelings, anxiety for no reason. I am very happy with it, the downside is that I'm bleeding like a light period a lot and have some breast pain. Getting that checked out soon."

9 / 10
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26 Report
  • Lou...
  • Taken for less than 1 month
  • April 28, 2018

For Atrophic Vaginitis "I was trying to manage my hot flashes/night sweats and trying to function on 3-4 hours of broken up sleep for over 5 years. This, as well as vaginal dryness, was having a negative impact on my quality of life. I have not yet gone a full year without my period, so I am still considered perimenopausal. (I am 54.) The first day on my patch, I had some jittery feelings, which were gone by the next day. Within 15 days, my hot flashes disappeared, and I’m actually sleeping up to 6 hours in a row!!"

9 / 10
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29 Report
  • JMa...
  • Taken for 1 to 6 months
  • December 14, 2018

For Postmenopausal Symptoms "I was diagnosed with sudden early menopause. Severe migraines (worse than I ever had), anxiety and panic attacks, insomnia (barely sleeping), depression, and night sweats. I really started feeling 90% better within a couple of weeks. I’m sleeping. Anxiety is minimal, and I’m sleeping again. Minimal side effects, but I’ve had bloating and bad indigestion."

8 / 10
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27 Report
  • rob...
  • Taken for less than 1 month
  • October 25, 2013

For Postmenopausal Symptoms "I've been on this patch for a short period of time, however, I can say it works fast! On the 2nd day using this product, my flashes and night sweats were less severe! I did experience nervousness on the 1st day, it lasted just a few hours, then went away. So far, so good."

8 / 10
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38 Report
  • Eli...
  • Taken for less than 1 month
  • June 6, 2023

For Postmenopausal Symptoms "I'm 51 years old, in perimenopause, and having terrible night sweats, heart palpitations, vaginal dryness, and anxiety. Was using vaginal estrogen cream with micronized progesterone for certain days each month. That helped with vaginal dryness, but not insomnia caused by night sweats. I just started the 0.5/0.14 patch. It instantly gave me the worst acid reflux, and I take a PPI daily. I mean the worst. I have a hiatal hernia, so GERD is a huge problem. Estrogen just may be off-limits for me since it relaxes the esophagus. I'm going to try to stick it out for a month to see if it gets better. The patch came off the first day, so I bought waterproof Nexcare medical tape to put over it. I hope this patch works for me. The palpitations are scary, and my anger/anxiety is even scarier for people who have to deal with me!!"

4 / 10
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9 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.