Comparing Enbrel vs Methotrexate
| Enbrel (etanercept) | Methotrexate |
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| Enbrel (etanercept) | Methotrexate |
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Prescription only
Enbrel is a subcutaneous injection that is usually self-administered once or twice a week for inflammatory conditions such as rheumatoid arthritis, psoriasis, psoriatic arthritis, or ankylosing... View more |
Prescription only
Methotrexate may be considered for the treatment of psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), mycosis fungoides, and certain cancers, such as ALL or... View more |
Related suggestions Rheumatoid Arthritis
Polyarticular Juvenile Idiopathic Arthritis
Popular comparisons
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| More about Enbrel (etanercept) | More about Methotrexate | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Enbrel has an average rating of 7.7 out of 10 from a total of 306 ratings on Drugs.com. 71% of reviewers reported a positive effect, while 14% reported a negative effect. |
Methotrexate has an average rating of 6.5 out of 10 from a total of 335 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 24% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Enbrel side effects |
View all Methotrexate side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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N/A |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Enbrel prices |
View all Methotrexate prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other etanercept brands include: Erelzi, Eticovo | Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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300 hours |
15 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 436 drugs are known to interact with Enbrel:
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A total of 718 drugs are known to interact with Methotrexate:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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November 02, 1998 |
December 07, 1953 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.