Disulfiram Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Disulfiram	Naltrexone	Acamprosate	Enter another drug to compare

Disulfiram

Naltrexone

Acamprosate

Prescription only

Prescribed for Alcohol Use Disorder. Disulfiram may also be used for purposes not listed in this medication guide.

Prescription only

Naltrexone is used as an adjunct to social and psychotherapy in the treatment of opioid and alcohol addiction. People taking naltrexone need to have completely stopped taking all types of opioids... View more

Prescription only

Prescribed for Alcohol Use Disorder. Acamprosate may also be used for purposes not listed in this medication guide.

More about Disulfiram

More about Naltrexone

More about Acamprosate

Ratings & Reviews

Disulfiram has an average rating of 7.8 out of 10 from a total of 141 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 19% reported a negative effect.

Naltrexone has an average rating of 7.9 out of 10 from a total of 599 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 16% reported a negative effect.

Acamprosate has an average rating of 8.5 out of 10 from a total of 272 ratings on Drugs.com. 81% of reviewers reported a positive effect, while 10% reported a negative effect.

View all 141 reviews

View all 599 reviews

View all 272 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Headaches (9.2%)
Nausea (7.1%)
Increased heart rate (6.4%)
Tiredness (6.4%)
Drowsiness (5.7%)
Rash (4.3%)
Sick (4.3%)

View all Disulfiram side effects

Nausea (8.2%)
Anxiety (7.2%)
Tiredness (6.5%)
Depression (6.0%)
Insomnia (5.7%)
Fatigue (5.0%)
Headaches (4.7%)

View all Naltrexone side effects

Anxiety (2.6%)
Diarrhea (2.6%)
Nausea (1.8%)
Tiredness (1.8%)
Depression (1.5%)
Dizziness (1.5%)
Tremors (1.5%)

View all Acamprosate side effects

Drug Class

Drugs used in alcohol dependence

Drugs used in alcohol dependence

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	30 tablet
Strength	250 mg
Per unit^*	$1.54
Cost^*	$46.22

View all Disulfiram prices

Quantity	20 each
Strength	50 mg
Per unit^*	$1.63
Cost^*	$32.62

View all Naltrexone prices

Quantity	30 each
Strength	333 mg
Per unit^*	$0.86
Cost^*	$25.85

View all Acamprosate prices

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Dosage Forms

Oral tablet

Oral tablet

Oral delayed release tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

7 hours

10 hours

33 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 205 drugs are known to interact with Disulfiram:

16 major drug interactions (45 brand and generic names)
174 moderate drug interactions (519 brand and generic names)
15 minor drug interactions (68 brand and generic names)

A total of 349 drugs are known to interact with Naltrexone:

34 major drug interactions (160 brand and generic names)
315 moderate drug interactions (1313 brand and generic names)

No known drug interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Alcohol/Food/Lifestyle Interactions

You should not drink alcoholic beverages or use medicines that contain alcohol during treatment... View more

Naltrexone may cause liver problems, and using it with other medications that can also affect the... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

First Approval Date

N/A

November 20, 1984

July 29, 2004

WADA Class View classifications

N/A

More Information

Patient Resources

Disulfiram uses

Naltrexone uses

Acamprosate uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Disulfiram Alternatives Compared

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