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Acamprosate Disease Interactions

There are 2 disease interactions with acamprosate.

Major

Acamprosate (applies to acamprosate) renal impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

The use of acamprosate is contraindicated in patients with severe renal impairment (creatinine clearance of =< 30 mL/min). A dose reduction is recommended in patients with moderate renal impairment.

Moderate

Acamprosate (applies to acamprosate) depression

Moderate Potential Hazard, Moderate plausibility.

Alcohol-dependent patients, including those patients being treated with acamprosate, should be monitored for the development of symptoms of depression or suicidal thinking. It is recommended to monitor patients being treated with acamprosate for worsening or the emergence of symptoms of depression or suicidality. Care should be exercised when using this agent in patients with depression.

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Acamprosate alcohol/food interactions

There is 1 alcohol/food interaction with acamprosate.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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