Comparing Depakote vs Lamotrigine
| Depakote (divalproex sodium) | Lamotrigine |
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| Depakote (divalproex sodium) | Lamotrigine |
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Prescription only
Depakote may be used in the treatment of epilepsy and mania, and to prevent migraines; however, people taking Depakote should be monitored for potentially fatal side effects such as liver failure... View more |
Prescription only
Lamotrigine is used to decrease the frequency and severity of seizures in some types of epilepsy and also to stabilize mood in bipolar I disorder. It is an oral tablet that is taken once or twice a... View more |
Related suggestions Migraine Prevention (Migraine Prophylaxis)
Seizures
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| More about Depakote (divalproex sodium) | More about Lamotrigine | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Depakote has an average rating of 6.3 out of 10 from a total of 329 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 26% reported a negative effect. |
Lamotrigine has an average rating of 7.8 out of 10 from a total of 1841 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 15% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Depakote side effects |
View all Lamotrigine side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Depakote prices |
View all Lamotrigine prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other divalproex sodium brands include: Depakote ER, Depakote Sprinkles | Lamictal, Lamictal CD, Lamictal ODT, Lamictal XR, Subvenite | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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16 hours |
25.7 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category D
Positive evidence of risk
When Treating Epilepsy And Manic Episodes Associated With Bipolar Disorder
Category X
Not for use in pregnancy
When Treating Migraine See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 424 drugs are known to interact with Depakote:
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A total of 286 drugs are known to interact with Lamotrigine:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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March 10, 1983 |
December 27, 1994 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.