Comparing Denosumab vs Zoledronic Acid
| Denosumab | Zoledronic acid |
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| Denosumab | Zoledronic acid |
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Prescription only
Denosumab is an injection that can be self-administered once every six months for the treatment of osteoporosis. It has been associated with an increased risk of fractures on discontinuation... View more |
Prescription only
Zoledronic acid strengthens bones and is used to manage several different bone-related conditions. Zoledronic acid injection (Reclast, 5 mg/100 mL) is used to treat and prevent postmenopausal or... View more |
Related suggestions Osteoporosis
Hypercalcemia of Malignancy
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| More about Denosumab | More about Zoledronic acid | ||||||||
| Ratings & Reviews | |||||||||
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Denosumab has an average rating of 3.0 out of 10 from a total of 396 ratings on Drugs.com. 17% of reviewers reported a positive effect, while 74% reported a negative effect. |
Zoledronic acid has an average rating of 5.0 out of 10 from a total of 411 ratings on Drugs.com. 35% of reviewers reported a positive effect, while 46% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||
View all Denosumab side effects |
View all Zoledronic acid side effects |
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| Drug Class | |||||||||
| Generic Availability | |||||||||
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N/A |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Zoledronic acid prices |
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| Dosage Forms | |||||||||
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N/A |
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| Brand Names | |||||||||
| Bomyntra, Conexxence, Jubbonti, Osenvelt, Ospomyv, Prolia, Stoboclo, Wyost, Xbryk, Xgeva View more | Aclasta, Reclast, Zometa | ||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||
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609.6 hours |
N/A |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category D
Positive evidence of risk
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||
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A total of 306 drugs are known to interact with Denosumab:
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A total of 123 drugs are known to interact with Zoledronic acid:
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| Alcohol/Food/Lifestyle Interactions | |||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||
| First Approval Date | |||||||||
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N/A |
December 28, 2015 |
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| WADA Class View classifications | |||||||||
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N/A |
N/A |
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| More Information | |||||||||
| Patient Resources | |||||||||
| Professional Resources | |||||||||
| Related Treatment Guide | |||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.