Comtrex Nighttime Cold & Cough Alternatives Compared
Comtrex Nighttime Cold & Cough | Benadryl | Diphenhydramine |
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Comtrex Nighttime Cold & Cough (acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine) | Benadryl (diphenhydramine) | Diphenhydramine |
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Over-the-counter
Prescribed for Sinus Symptoms, Cough, Cough and Nasal Congestion, Cold Symptoms, Nasal Congestion, Rhinorrhea. Comtrex Nighttime Cold & Cough may also be used for purposes not listed in this medication guide. View more |
Prescription and OTC
Benadryl is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side effect... View more |
Prescription and OTC
Diphenhydramine is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side... View more |
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More about Comtrex Nighttime Cold & Cough (acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine) | More about Benadryl (diphenhydramine) | More about Diphenhydramine | ||||||||||||||||
Ratings & Reviews | ||||||||||||||||||
Be the first to share your experience with this drug. |
Benadryl has an average rating of 7.2 out of 10 from a total of 76 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 19% reported a negative effect. |
Diphenhydramine has an average rating of 5.4 out of 10 from a total of 530 ratings on Drugs.com. 43% of reviewers reported a positive effect, while 41% reported a negative effect. |
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Drug Class | ||||||||||||||||||
Side Effects | ||||||||||||||||||
See also: Comtrex Nighttime Cold & Cough side effects in more detail. |
See also: Benadryl side effects in more detail. |
See also: diphenhydramine side effects in more detail. |
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Generic Availability | ||||||||||||||||||
N/A |
N/A |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Benadryl prices |
View all diphenhydramine prices |
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Dosage Forms Available | ||||||||||||||||||
N/A |
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Brand Names | ||||||||||||||||||
Other acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine brands include: Alka-Seltzer Plus Maximum Strength Cold & Cough, Alka-Seltzer Plus Maximum Strength Cold & Cough Liquid Gels, Alka-Seltzer Plus Maximum Strength Sinus Congestion & Pain PowerFast Fizz, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Alka-Seltzer Plus Severe Cold & Flu PowerFast Fizz, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Codral Cold and Flu + Cough Day and Night, Cold Multi-Symptom (Nighttime), Comtrex Cold & Cough Day Night, Giltuss Children's Multi-Symptom Cold & Flu, Giltuss Multi-Symptom Cold & Flu, Multi Symptom Cold (Night Formula), Multi Symptom Cold Relief, PediaCare Flu Plus Acetaminophen, PediaCare Multi-Symptom Cold Plus Acetaminophen, Theraflu Nighttime Severe Cold & Cough Caplets, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Triaminic Multi-Symptom Fever & Cold, Tylenol Children’s Cold + Flu, Tylenol Cold Head Congestion Day and Night, Tylenol Cold Head Congestion Nighttime, Tylenol Cold Multi-Symptom Nighttime, XL-3 Xtra Cold and Cough View more | Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | ||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||
30 hours |
9.3 hours |
9.3 hours |
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CSA Schedule ** View glossary of terms | ||||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | ||||||||||||||||||
Category N
Not classified
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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Drug Interactions | ||||||||||||||||||
A total of 618 drugs are known to interact with Comtrex Nighttime Cold & Cough:
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A total of 447 drugs are known to interact with Benadryl:
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A total of 447 drugs are known to interact with diphenhydramine:
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Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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Disease Interactions | ||||||||||||||||||
First Approval Date | ||||||||||||||||||
N/A |
March 04, 1946 |
March 04, 1946 |
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WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||
N/A |
N/A |
N/A |
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More Information | ||||||||||||||||||
Patient resources | ||||||||||||||||||
Professional Resources | ||||||||||||||||||
N/A |
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Related Treatment Guide | ||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.