Comparing Clonidine vs Lofexidine
| Clonidine | Lofexidine |
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| Clonidine | Lofexidine |
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Prescription only
Clonidine can be used to lower blood pressure and extended-release forms are used to treat ADHD; however, it causes sedation, and tolerance can develop to its blood pressure-lowering effects... View more |
Prescription only
Lofexidine is used to ease the symptoms due to abruptly stopping opioids in people with opioid addiction (opioid use disorder). It is given for up to 14 days, based on symptoms and peak withdrawal... View more |
Related suggestions Opiate Withdrawal
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| More about Clonidine | More about Lofexidine | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Clonidine has an average rating of 7.1 out of 10 from a total of 774 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 21% reported a negative effect. |
Lofexidine has an average rating of 6.6 out of 10 from a total of 50 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 32% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Clonidine side effects |
View all Lofexidine side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Clonidine prices |
View all Lofexidine prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Catapres, Catapres-TTS, Clonidine ER, Duraclon, Kapvay, Nexiclon XR, Onyda XR | Lucemyra | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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15 hours |
12 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 375 drugs are known to interact with Clonidine:
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A total of 551 drugs are known to interact with Lofexidine:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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September 03, 1974 |
May 16, 2018 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
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| More Information | |||||||||||||||||
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| Related Treatment Guide | |||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.