Comparing Clonidine vs Guanfacine
| Clonidine | Guanfacine |
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| Clonidine | Guanfacine |
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Prescription only
Clonidine can be used to lower blood pressure and extended-release forms are used to treat ADHD; however, it causes sedation, and tolerance can develop to its blood pressure-lowering effects... View more |
Prescription only
Guanfacine is used to treat high blood pressure and the extended-release form (brand name Intuniv) is approved for the treatment of ADHD. Guanfacine can cause sedation, especially on therapy... View more |
Related suggestions High Blood Pressure (Hypertension)
ADHD (Attention Deficit Hyperactivity Disorder)
Tourette's Syndrome
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| More about Clonidine | More about Guanfacine | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Clonidine has an average rating of 7.1 out of 10 from a total of 774 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 21% reported a negative effect. |
Guanfacine has an average rating of 6.1 out of 10 from a total of 317 ratings on Drugs.com. 50% of reviewers reported a positive effect, while 32% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Clonidine side effects |
View all Guanfacine side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Clonidine prices |
View all Guanfacine prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Catapres, Catapres-TTS, Clonidine ER, Duraclon, Kapvay, Nexiclon XR, Onyda XR | Intuniv | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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15 hours |
18 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 375 drugs are known to interact with Clonidine:
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A total of 483 drugs are known to interact with Guanfacine:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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September 03, 1974 |
October 27, 1986 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.