Clomipramine Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Clomipramine	Zoloft (sertraline)	Sertraline	Enter another drug to compare

Clomipramine

Zoloft (sertraline)

Sertraline

Prescription only

Prescribed for Obsessive Compulsive Disorder, Irritable Bowel Syndrome, Depression, Panic Disorder, Premature Ejaculation, Sleep Paralysis, Trichotillomania. Clomipramine may also be used for... View more

Prescription only

Zoloft is a brand name for sertraline which is an effective antidepressant with less potential for drowsiness than many other antidepressants. It belongs to the group of medicines called selective... View more

Prescription only

Sertraline is an effective antidepressant with less potential for drowsiness than other antidepressants. Headaches, nausea, diarrhea, weight loss, insomnia, tremors, and sexual dysfunction are the... View more

More about Clomipramine

More about Zoloft (sertraline)

More about Sertraline

Ratings & Reviews

Clomipramine has an average rating of 8.0 out of 10 from a total of 312 ratings on Drugs.com. 76% of reviewers reported a positive effect, while 13% reported a negative effect.

Zoloft has an average rating of 7.3 out of 10 from a total of 1972 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 18% reported a negative effect.

Sertraline has an average rating of 7.3 out of 10 from a total of 4563 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 18% reported a negative effect.

View all 312 reviews

View all 1972 reviews

View all 4563 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Dry mouth (15.1%)
Sexual dysfunction (10.9%)
Constipation (10.6%)
Anxiety (7.7%)
Weight gain (7.1%)
Insomnia (6.4%)
Tiredness (5.1%)

View all Clomipramine side effects

Anxiety (14.7%)
Nausea (11.2%)
Insomnia (9.5%)
Sexual dysfunction (8.1%)
Tiredness (7.0%)
Depression (6.6%)
Loss of appetite (6.5%)

View all Zoloft side effects

Anxiety (17.9%)
Nausea (12.2%)
Insomnia (10.7%)
Headaches (7.7%)
Tiredness (7.2%)
Sexual dysfunction (6.9%)
Depression (6.7%)

View all Sertraline side effects

Drug Class

Tricyclic antidepressants

Selective serotonin reuptake inhibitors

Selective serotonin reuptake inhibitors

Generic Availability

Lower cost generic

Lower cost generic approved

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	30 each
Strength	25 mg
Per unit^*	$8.16 - $10.77
Cost^*	$244.85 - $323.24

View all Clomipramine prices

Quantity	30 tablet
Strength	100 mg
Per unit^*	$16.24
Cost^*	$487.07

View all Zoloft prices

Quantity	50 each
Strength	100 mg
Per unit^*	$0.58
Cost^*	$28.98

View all Sertraline prices

Get free Discount Card

Dosage Forms

Oral capsule

Oral concentrate
Oral tablet

Oral capsule
Oral concentrate
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

18 hours

66 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 792 drugs are known to interact with Clomipramine:

143 major drug interactions (602 brand and generic names)
624 moderate drug interactions (2556 brand and generic names)
25 minor drug interactions (159 brand and generic names)

A total of 673 drugs are known to interact with Zoloft:

157 major drug interactions (612 brand and generic names)
511 moderate drug interactions (2143 brand and generic names)
5 minor drug interactions (25 brand and generic names)

A total of 673 drugs are known to interact with Sertraline:

157 major drug interactions (612 brand and generic names)
511 moderate drug interactions (2143 brand and generic names)
5 minor drug interactions (25 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Grapefruit, grapefruit juice, and cranberry juice may cause the clomiPRAMINE levels in your body to... View more
Ask your doctor before using clomiPRAMINE together with alcohol, this can alter the effects of... View more

Using sertraline together with alcohol may increase side effects such as dizziness, drowsiness... View more

Using sertraline together with alcohol may increase side effects such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

December 29, 1989

December 30, 1991

WADA Class View classifications

N/A

More Information

Patient Resources

Zoloft uses

Sertraline uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Clomipramine Alternatives Compared

Further information

Compare Drugs