Avandamet Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Avandamet (metformin / rosiglitazone)	Semaglutide	Tirzepatide	Enter another drug to compare

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Avandamet (metformin / rosiglitazone)	Semaglutide	Tirzepatide	Enter another drug to compare
Prescription only Prescribed for Diabetes - Type 2. Avandamet may also be used for purposes not listed in this medication guide.	Prescription only Semaglutide lowers blood sugar levels by mimicking the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It is taken... View more	Prescription only Prescribed for Weight Loss (Obesity/Overweight), Diabetes - Type 2. Tirzepatide may also be used for purposes not listed in this medication guide.	Related suggestions Diabetes, Type 2 Metformin Ozempic Rybelsus Mounjaro Januvia Victoza
More about Avandamet (metformin / rosiglitazone)	More about Semaglutide	More about Tirzepatide
Ratings & Reviews
Avandamet has an average rating of 6.0 out of 10 from a total of 3 ratings on Drugs.com. 50% of reviewers reported a positive effect, while 50% reported a negative effect.	Semaglutide has an average rating of 6.9 out of 10 from a total of 2357 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 22% reported a negative effect.	Tirzepatide has an average rating of 8.7 out of 10 from a total of 1454 ratings on Drugs.com. 81% of reviewers reported a positive effect, while 5% reported a negative effect.
View all 3 reviews	View all 2357 reviews	View all 1454 reviews
Drug Class
Antidiabetic combinations	Incretin Mimetics (GLP-1 Agonists)	Incretin Mimetics (GLP-1 Agonists)
Side Effects
Avandamet side effects	Semaglutide side effects	Tirzepatide side effects
Generic Availability
No lower cost generic approved	N/A	N/A
Pricing and Coupons * Prices are without insurance
We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.
Get free Discount Card	Get free Discount Card	Get free Discount Card

Dosage Forms Available
Oral tablet	N/A	N/A
Brand Names
N/A	Ozempic, Rybelsus, Wegovy	Mounjaro, Zepbound
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.
6.2 hours	168 hours	120 hours
CSA Schedule ** View glossary of terms
N Not a controlled drug Is not subject to the Controlled Substances Act.	N Not a controlled drug Is not subject to the Controlled Substances Act.	N Not a controlled drug Is not subject to the Controlled Substances Act.
Pregnancy Category
C Category C Risk cannot be ruled out See the full pregnancy warnings document.	Summary unavailable. See the full pregnancy warnings document.	Summary unavailable. See the full pregnancy warnings document.
Drug Interactions
A total of 429 drugs are known to interact with Avandamet: 29 major drug interactions (139 brand and generic names) 391 moderate drug interactions (1929 brand and generic names) 9 minor drug interactions (35 brand and generic names)	A total of 266 drugs are known to interact with Semaglutide: 15 major drug interactions (34 brand and generic names) 250 moderate drug interactions (1425 brand and generic names) 1 minor drug interactions (10 brand and generic names)	A total of 411 drugs are known to interact with Tirzepatide: 15 major drug interactions (34 brand and generic names) 395 moderate drug interactions (2255 brand and generic names) 1 minor drug interactions (10 brand and generic names)
Alcohol/Food/Lifestyle Interactions
MetFORMIN should be taken with meals, and excessive alcohol intake (either short-term binge... View more	Semaglutide may affect the absorption of other medications that you take by mouth. In some cases... View more Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more	Tirzepatide may affect the absorption of other medications that you take by mouth. In some cases... View more Talk to your doctor before using alcohol together with tirzepatide. Alcohol may affect blood... View more
Disease Interactions
Lactic acidosis Liver disease Renal dysfunction Myocardial infarction CHF Type I diabetes Hypoglycemia B12 deficiency Edema Liver disease Macular edema Premenopausal anovulation Weight gain Anemia	Suicidal behavior and ideation Thyroid cancer GI adverse events Hypoglycemia Pancreatitis Retinopathy	Thyroid cancer Acute kidney injury Pancreatitis Retinopathy Severe GI disease
First Approval Date
October 10, 2002	December 05, 2017	N/A
WADA Class View World Anti-Doping Agency classifications.
N/A	N/A	N/A
More Information
Side effects Pregnancy warnings Dosage information Drug images Drug interactions	Side effects Pregnancy warnings Breastfeeding warnings Dosage information Drug interactions Support group En Español	Side effects Pregnancy warnings Breastfeeding warnings Dosage information Drug interactions Support group En Español
Patient resources
Avandamet uses	Semaglutide uses	Tirzepatide uses
Professional Resources
N/A	Monograph (AHFS) Prescribing information	Monograph (AHFS) Prescribing information
Related Treatment Guide
Diabetes - Type 2	Weight Loss (Obesity/Overweight) Cardiovascular Risk Reduction Diabetes - Type 2	Weight Loss (Obesity/Overweight) Diabetes - Type 2

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

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