Comparing Auvelity vs Spravato
| Auvelity (bupropion / dextromethorphan) | Spravato (esketamine) |
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| Auvelity (bupropion / dextromethorphan) | Spravato (esketamine) |
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Prescription only
Auvelity is an oral combination antidepressant tablet containing bupropion and dextromethorphan that has a novel way of working to treat adults with severe depression. Research has shown it is... View more |
Prescription only
Prescribed for Major Depressive Disorder, Depression. Spravato may also be used for purposes not listed in this medication guide. |
Related suggestions Major Depressive Disorder
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| More about Auvelity (bupropion / dextromethorphan) | More about Spravato (esketamine) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Auvelity has an average rating of 8.6 out of 10 from a total of 140 ratings on Drugs.com. 79% of reviewers reported a positive effect, while 6% reported a negative effect. |
Spravato has an average rating of 6.3 out of 10 from a total of 125 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 29% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Auvelity side effects |
View all Spravato side effects |
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| Generic Availability | |||||||||||||||||
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N/A |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Auvelity prices |
View all Spravato prices |
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| Brand Names | |||||||||||||||||
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N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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30 hours |
12 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Moderate abuse potential
Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |
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| Pregnancy Category | |||||||||||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 695 drugs are known to interact with Auvelity:
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A total of 297 drugs are known to interact with Spravato:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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August 18, 2022 |
N/A |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.