Comparing Aspirin vs Methotrexate
| Aspirin | Methotrexate |
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| Aspirin | Methotrexate |
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Prescription and OTC
Aspirin relieves pain and inflammation and helps to thin the blood. It is used to treat and prevent a wide range of different conditions. Higher dosages are associated with stomach irritation and... View more |
Prescription only
Methotrexate may be considered for the treatment of psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), mycosis fungoides, and certain cancers, such as ALL or... View more |
Related suggestions Rheumatoid Arthritis
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| More about Aspirin | More about Methotrexate | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Aspirin has an average rating of 7.8 out of 10 from a total of 51 ratings on Drugs.com. 71% of reviewers reported a positive effect, while 14% reported a negative effect. |
Methotrexate has an average rating of 6.5 out of 10 from a total of 335 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 24% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
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View all Aspirin side effects |
View all Methotrexate side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Aspirin prices |
View all Methotrexate prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Acetylsalicylic Acid, Acuprin 81, Arthritis Foundation Pain Reliever, Arthritis Pain, Ascriptin, Ascriptin Enteric, Ascriptin Maximum Strength, Aspergum, Aspi-Cor, Aspir 81, Aspir-Low, Aspirin Lite Coat, Aspirin Low Strength, Aspiritab, Aspirtab, Bayer Advanced Aspirin, Bayer Aspirin, Bayer Aspirin Extra Strength Plus, Bayer Aspirin Regimen, Bayer Aspirin with Heart Advantage, Bayer Children's Aspirin, Bayer Women's Aspirin With Calcium, Buffasal, Buffered Aspirin, Bufferin, Bufferin Arthritis Strength, Bufferin Extra Strength, Bufferin Low Dose, Buffex, Durlaza, Easprin, Ecotrin, Ecotrin Adult Low Strength, Ecotrin Maximum Strength, Ecpirin, Empirin, Entaprin, Entercote, Extra Strength Bayer, Fasprin, Genacote, Gennin-FC, Genprin, Halfprin, Heartline, Medi-Seltzer, Migralex, Miniprin, Norwich Aspirin, St. Joseph 81 mg Aspirin Enteric Safety-Coated, St. Joseph 81 mg Chewable Aspirin, Tri-Buffered Aspirin, Vazalore View more | Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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10 hours |
15 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category N
Not classified
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 369 drugs are known to interact with Aspirin:
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A total of 716 drugs are known to interact with Methotrexate:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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June 25, 1965 |
December 07, 1953 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
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| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.