Comparing Amitriptyline vs Clonidine
| Amitriptyline | Clonidine |
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| Amitriptyline | Clonidine |
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Prescription only
Amitriptyline is an effective antidepressant but it may cause drowsiness initially and a withdrawal syndrome with abrupt discontinuation. It may be used off-label to treat other conditions such as... View more |
Prescription only
Clonidine can be used to lower blood pressure and extended-release forms are used to treat ADHD; however, it causes sedation, and tolerance can develop to its blood pressure-lowering effects... View more |
Related suggestions Migraine Prevention (Migraine Prophylaxis)
Hyperhidrosis
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| More about Amitriptyline | More about Clonidine | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Amitriptyline has an average rating of 7.6 out of 10 from a total of 1805 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 16% reported a negative effect. |
Clonidine has an average rating of 7.1 out of 10 from a total of 774 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 21% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Amitriptyline side effects |
View all Clonidine side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Amitriptyline prices |
View all Clonidine prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
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N/A |
Catapres, Catapres-TTS, Clonidine ER, Duraclon, Kapvay, Nexiclon XR, Onyda XR | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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16 hours |
15 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 716 drugs are known to interact with Amitriptyline:
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A total of 375 drugs are known to interact with Clonidine:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
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| First Approval Date | |||||||||||||||||
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April 07, 1961 |
September 03, 1974 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
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| Related Treatment Guide | |||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.