Trintellix for Major Depressive Disorder User Reviews (Page 2)

• CD9...
• Taken for less than 1 month
• December 26, 2019

"Huge difference with taking Trintellix in just a couple of weeks. I have never responded well to antidepressants. It must get to the right receptors. First time I felt positive and hopeful for the future in over 10 years."

• qua...
• Taken for 1 to 6 months
• February 18, 2025

"I've been scared of taking antidepressants all my life. Scared of it making me feel numb. It ruining my creativity. Trintellix is the best thing that has ever happened to me. I still feel myself, I can still cry, I can still feel excited. But for the first time in more than 10 years, I can live my life without suffering every moment of it."

• Yay...
• Taken for 6 months to 1 year
• September 26, 2023

"I tried different medications for around a year and a half, including most of the SSRI family, and some anticonvulsants and antipsychotics off-label. I have GAD and MDD. Trintellix was the only thing to finally work for me. It was a life saver. No side effects to speak of. I take 20mg. Manufacturer's coupon brings it down to only about $35 a month. So grateful I found this."

• Wor...
• Taken for less than 1 month
• March 12, 2024

"I have been on 5 mg Trintellix for 1 month. The only side effects I've had are somewhat dry mouth sometimes, and not being able to sleep as well as I used to. Other than those 2 things, it has worked great for me! For the first 1-2 weeks, I did continue to have some bad days, but starting about week 3, the bad times became less extreme and have continued to do so. My insurance wouldn't pay for it, so I applied for assistance on the manufacturer's website, and received it for free."

• eli...
• August 9, 2016

"This medication is a game changer. I've been on 20 mg once per day (at night works best for me) for about 5 months. It is by far the best medication I have tried. Initially started on 10 mg, and raised my dose 2 months in. Pros: Overall heightened mood, more energy, ability to feel array of emotions, no sexual dysfunction (many antidepressants are famous for causing this), increases ability to enjoy activities I used to love. Neutral: does not treat my anxiety very well alone. Cons: nausea when starting the medication and increasing dose, more expensive than traditional antidepressants. Overall, I love this medication. I will definitely continue on it. I have seen a big improvement since trying Trintellix."

• Ron...
• Taken for 1 to 2 years
• January 21, 2025

"It's the only thing I have found to work. Unfortunately, I can't afford it anymore. I am on disability and Medicare, on a budget, and was paying 100 a month for Trintellix. Now this year, there is a deductible on it for 340, and after that, 100 a month! If I become so depressed, something happens, you will know why! Just like a drug dealer teasing you with their drugs and then going up on it!"

• jew...
• April 8, 2014

"Great experience so far. Month three, ramping up to 20 mg a day. Constipation side effect eliminated by 2 fiber capsules a day. No sexual side effects and feeling much more like myself! No weight gain!"

• Bel...
• May 11, 2019

"Prescribed 10 mg a day of Trintellix for depression, and the first 10 days I was sick to my stomach and itching, so I take an antihistamine at the same time at bedtime. Day 11 started feeling markedly better, nausea was gone, still itching, but less. Day 14 my overall feeling was 50 percent better than when I started the drug. Today, day 16 saw my doctor again. I had lost weight, my overall anxiety is much better, the depression 70 percent better. All my aches and pains have disappeared. The doctor gave me 2 months of samples and told me to come back in a month if I thought I needed to, otherwise continue as directed. I've been on multiple antidepressants over the years, none worked even half as well as the Trintellix"

• mlo...
• January 6, 2021

"I was on every drug in the book for depression: Prozac, Wellbutrin, Pristiq, and Cipralex, nothing took the edge off at all. I lost my mother to depression in July of 2019. Nothing could be worse. I was not on anything but Prozac at the time, and I wasn't doing well. Addicted to benzos, I was struggling. My doctor placed me on Trintellix, 10 mg. He was kind enough to give me samples until I got coverage. I had a bit of a setback and fell into depression six months later. I was boosted to 20 mg, and now I am doing fantastic. Depressive episodes do come back for a few days at a time, but they are easier to handle if you get back into a routine and force yourself. I think this is a great drug, I lost all hope in antidepressants previously."

• Was...
• Taken for 1 to 6 months
• September 24, 2014

"I had been diagnosed with Major Depressive Disorder and have been treated with medicines that, at that time, were the best. Venlafaxine being the latest. However, the effects were decreasing over time. After 12 years and having so many side effects, now I am on Trintellix 20mg daily...wow, there is life. My mood is elevated, my outlook, self-esteem, and confidence have returned to normal. My energy level has skyrocketed. My sleep is more restful. Negative thoughts are diminished. Day-to-day living is now controllable. Clear thought process, not a drugged feeling. I am a very content person. Focus on the enabling versus the negativity. Started on 10mg daily, increased to 20mg after 3 weeks, and a slow reduction in my venlafaxine. One side effect is nausea I noted, but a dry snack helps."

• Anonymous
• Taken for 1 to 6 months
• January 15, 2025

"Trintellix has been the most effective antidepressant I've ever taken. I've been on numerous SSRIs (and one SNRI... not for me, never again). It took the entire four weeks to start working, but once it did, I immediately saw a difference in my MDD symptoms. I described it to a colleague that my depression has lifted completely. I have motivation to get out of bed and take part in social activities again after work. I'm eating normally again and haven't experienced any side effects from the medication. I'm prescribed 10 mg Trintellix and being treated specifically for MDD. Trintellix isn't helpful for my anxiety at all. My psychiatrist identified some preexisting Bipolar II symptoms (mostly mood swings) and has me on a low-dose mood stabilizer, generic Lamictal, to smooth the ups and downs. So far, so good."

• tar...
• Taken for 1 to 6 months
• June 3, 2014

"Week four on Trintellix, 10mg to start, upped to 20mg for 3 weeks now, no side effects as of yet. I'm feeling better every day it seems. I feel happy again, less agitation, more energy, and motivation. My personal relationships, which were quickly deteriorating, are seeming to return to normal! My only wish is that I'd found this medication much sooner. Best wishes to anyone else with this medication! (My insurance is needing a pre-authorization to cover this medication, just a note for others.)"

• Reb...
• Taken for 6 months to 1 year
• November 29, 2018

"I used to be on generic escitalopram for 6-7 years. It worked really well at the time, but as I was now becoming an adult (21 now), my major depressive episodes were happening more frequently. I had more adult stress; full-time student, part-time worker, full-time bills. It was becoming too much. I switched psychiatrist and psychologist due to personal reasons and insurance. My new psychiatrist gave me free samples of Trintellix to try for a month. She said it's newer than escitalopram, it's usually faster and has more SSRIs. After 6 days, I began to feel really great. I was able to pay attention in lectures again, I felt so energetic that I started going back to the gym, and I just felt more like myself again. Like a 2.0. It could've been a placebo effect, but after taking it for almost a year now, I can tell you I feel incredible :)"

• ric...
• Taken for 5 to 10 years
• January 14, 2024

"I had major depressive disorder for decades and had been on every antidepressant med., so when I saw a psychiatrist (2014 or 2015) at the insistence of my psychologist, the psychiatrist confirmed that I had been on every antidepressant med. with, at most, brief benefit. She suggested trying a new med., which was originally called Brintellix. My depressive symptoms had included long periods - weeks, months - of extreme depression in reaction to even minor triggering events. I was in one of the long periods of extreme depression when I began taking this medication. The morning after my first dose, I was relieved of the intensity and even of a mildly depressed affect. Since then, I have had brief periods of very disturbing depression, but they have been only periods of hours. I have not had any periods of depressive affect or behavior lasting more than a few hours. I have had mild symptoms from time to time, but none where I could not function. I can still feel hopeless or sometimes."

• Tri...
• Taken for 1 to 2 years
• June 5, 2020

"Definitely mixed feelings about Trintellix after being on this medication for a year. Prior to this, I took Paxil and abandoned that horror due to reduced emotions and feelings for anything or anyone. I began Trintellix and you'd swear I was bipolar (which I'm not). I wake up some mornings, take a 20 mg tablet, and feel happy but severely anxious. Throughout the day, the anxiety builds up until the evening. The evening sucks. The anxiety slowly builds into depression, I wake up the next day and it happens all over again, like Groundhog Day."

• Mik...
• Taken for 6 months to 1 year
• March 31, 2023

"Trintellix has been a lifesaver. It’s extremely powerful, and the side effects are low. It works rather quickly compared to other antidepressants. It’s kind of like Wellbutrin, as the mechanism of action is different from most SSRIs/SNRIs. It has its own unique feeling. Not as bad emotional blunting and horrible sexual side effects like Zoloft or Prozac. It’s very expensive with no generic available, but the insurance companies are starting to cover it, and there is supposed to be a generic available in 2027, hopefully. I was in a dark place, and it pulled me out. Also, it’s not extremely addictive like other antidepressants."

• JRH...
• November 12, 2016

"I started this med in September of 2015. I have been on 30 psychotropic medications over the past twenty years to manage my MDD and anxiety. Had 30-ish ECT treatments as well. Also have regular CBT therapy. Nothing was working for more than a couple of months. However, I started Trintellix and saw improvement within a month. After a decade of a depressive episode that I never got into remission from, I was in partial remission. No, it isn't complete remission but I've dealt with the fact that that may not be in the cards for me. I haven't had active suicidal thoughts in a year. Until that point, I hadn't gone without suicidal thoughts for more than a month. This drug has been a lifesaver for me. No side effects."

• Rae...
• Taken for 6 months to 1 year
• November 6, 2019

"I have noticed positive improvements in my mood and fatigue since switching from Effexor to Trintellix. I’m not terribly flatlined in my emotions (like with Effexor), but there are other side effects I’ve experienced. Nausea is a consistent side effect of Trintellix, and I typically get it about 20 minutes after taking my meds, and then it fades after a while. Also, I’ve noticed appetite-suppressing effects, which I’m not upset about since I gained considerable weight on my last medication. Overall, I’m satisfied with Trintellix and would recommend it to someone who hasn’t done well on other antidepressants."

• Bet...
• November 21, 2016

"I have been on medication for about 4 weeks. Antidepressants have always been my best friend. This drug has been remarkable thus far. No major side effects physically. The main problem I am dealing with are dreams, but mostly nightmares. I take my medication usually before lunch. I missed it one day and took it before bedtime, never again. I was awake most of the night. I am successfully weaning off of Xanax & THC during this period with great success. No thoughts of suicide. Life seems better. I'm in my late 40s and a full-time student. I would totally recommend this medication because this is the first time in life that I feel more myself. Hey, I can even crack a smile... something I haven't done in years."

• bre...
• Taken for 1 to 6 months
• September 16, 2014

"I have been pretty medicine resistant to most medications. The best medication for me was Zoloft until it lost its effectiveness on me. I have been on Trintellix for about a month now, was upped to 20mg last week, and it is just amazing for me. I feel a sense of happiness and hope that I haven't felt in a long time. I really didn't see as much improvement until the medication was upped to 20 mg, then so far it has been awesome. I have had no side effects other than the first few days I was a little antsy and lightheaded."

• Ali...
• Taken for less than 1 month
• May 12, 2023

"I took Trintellix for three weeks due to my previous antidepressant losing effectiveness. I started with 5 mg and had gone up to 10 mg when I was overwhelmed by anxiety. Because you can’t just quit, I had to wean myself off the drug. I dropped to 5 mg for a week and then finally stopped. I still have symptoms of anxiety as I wait for the effects to go away. I had never experienced anxiety until I started taking this drug. I am now dealing with major depression and anxiety at the same time. I do not endorse the use of this drug."

• Gle...
• Taken for less than 1 month
• December 17, 2016

"I have been taking this med for about a month. I am taking it with Wellbutrin 300 mg. I am taking 5 mg. It has helped tremendously. The first day I took it, I was nauseous & had a headache. I have been taking it at night, about an hour before bedtime, and have not had either symptom again. My energy level has increased. I have been able to do things I need to do, more importantly I have been able to do some of the things I want to do. The feeling that life was too overwhelming is gone. I have my sense of humor back and I am not on the roller coaster of crying at the drop of a hat or being so angry I wanted to smack the skin off someone's face. I am very pleased with this medicine & hope it continues to do as well as it has been doing for me."

• RDC...
• Taken for 1 to 6 months
• September 22, 2022

"First, I want to start by saying that a majority of the negative reviews are from people coming off a previous antidepressant and starting Trintellix. The 'side effects' you may think are from Trintellix could be withdrawal from your previous antidepressant! I've gone through this six times with switching from one to another, and the withdrawals from the previous medication kick in normally by day three and can last weeks or months depending on the med you're switching off from. With that being said, if possible, always try to give the new med at least a full three months to adjust, and the withdrawals from the previous med should have subsided. I'm not saying some of the side effects aren't from Trintellix, but the majority of the major side effects people feel are withdrawal symptoms. If you stayed reading this long, onto the review. I'm coming off Prozac onto Trintellix. Slight nausea, but nothing major. Take with food. Helps keep the sadness away. Works for me."

• Lov...
• Taken for 1 to 6 months
• May 19, 2017

"I was diagnosed with major depression after years of dealing with terrible Rheumatoid arthritis that has limited my mobility. My doctor prescribed me 3 different antidepressants and after Cymbalta gave me head zaps and my anxiety was causing panic attacks, he switched me to Trintellix. I started on the 5 mg while I was weaning off 60 mg of Cymbalta. The nausea was so bad. I would like to think I have a pretty strong stomach, but this med made me sick like when I was pregnant. I stuck with it and 3 weeks in at 10 mg, I feel fantastic! I'm so glad I stuck with it! I'm laughing again and my motivation is incredible! It was so worth it! If you're debating it, stick with it through the nausea to see if it works for you. I'm truly thankful!"

• LAa...
• May 27, 2017

"Best (and most expensive) medication I've ever been on. I've been prescribed every other SSRI, and they gave me side effects of sleepiness and indifference. I have only experienced slight nausea for about 2 hours, 15 minutes after I take my Trintellix. This only lasted the first two weeks. The nausea is the only reason I give this a 9/10. Anxiety and paranoia have been greatly reduced, energy is amazing, and no sleepiness or indifference. I had genetic testing done, and I am deficient in folic acid and don't produce it on my own. I complement the Trintellix with methylfolate by Biotics Lab (Deplin is expensive). I'm happier than I've ever been, and no sexual dysfunctions have happened, so I am extremely thankful for this medication."