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Venlafaxine User Reviews & Ratings

Brand names: Effexor, Effexor XR

Venlafaxine has an average rating of 6.4 out of 10 from a total of 2,736 reviews on Drugs.com. 54% of reviewers reported a positive experience, while 28% reported a negative experience.

Condition Avg. Rating Reviews Compare
Depression
6.0
1023 reviews for Depression 76 medications
Anxiety
6.5
421 reviews for Anxiety 52 medications
Major Depressive Disorder
6.5
260 reviews for Major Depressive Disorder 51 medications
Generalized Anxiety Disorder
6.8
244 reviews for Generalized Anxiety Disorder 7 medications
Anxiety and Stress Off-label
6.6
188 reviews for Anxiety and Stress 6 medications
Hot Flashes Off-label
6.7
146 reviews for Hot Flashes 19 medications
Panic Disorder
6.5
85 reviews for Panic Disorder 18 medications
Bipolar Disorder Off-label
6.7
77 reviews for Bipolar Disorder 36 medications
Social Anxiety Disorder
7.2
63 reviews for Social Anxiety Disorder 6 medications
Fibromyalgia Off-label
6.7
52 reviews for Fibromyalgia 15 medications
Obsessive Compulsive Disorder Off-label
7.6
44 reviews for Obsessive Compulsive Disorder 9 medications
Post Traumatic Stress Disorder Off-label
6.5
33 reviews for Post Traumatic Stress Disorder 2 medications
Postpartum Depression
7.1
24 reviews for Postpartum Depression 9 medications
Migraine Off-label
5.6
22 reviews for Migraine 89 medications
Irritable Bowel Syndrome Off-label
8.2
18 reviews for Irritable Bowel Syndrome 153 medications
Autism
7.5
16 reviews for Autism 8 medications
Cataplexy Off-label
7.3
4 reviews for Cataplexy 2 medications
Premenstrual Dysphoric Disorder Off-label
9.5
4 reviews for Premenstrual Dysphoric Disorder 49 medications
Bulimia
8.5
3 reviews for Bulimia 4 medications
Dissociative Identity Disorder Off-label
8.5
3 reviews for Dissociative Identity Disorder 4 medications
Somatoform Pain Disorder Off-label
4.0
3 reviews for Somatoform Pain Disorder 12 medications
Vulvodynia
4.5
3 reviews for Vulvodynia 1 medications

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Reviews for Venlafaxine

  • Dor...
  • Taken for 5 to 10 years
  • January 3, 2021

Effexor XR (venlafaxine) for Depression "In a few paragraphs, I can gladly proclaim this medication saved my life in so many ways! I had never felt content until I took Effexor. The grass was greener, the music was even more beautiful, I am now kind and patient again; I am simply happy! I don't need to constantly seek out pleasurable things to make life more exciting anymore. I’m not so emotionally vulnerable. For the first time in my life, I can READ! My ADHD has diminished 70% - 90%! Whether it be from ADHD, anhedonia or both, I can FINALLY enjoy the simple things in life. Lastly and miraculously, my IQ went up 15 - 20 points! My thought process is much more clear, and I LOVE reading and learning! My newfound curiosity fuels my joy for living and learning. I want to thank the people who created this drug. I am not only myself again, but I’m someone I never even knew I was capable of being!"

10 / 10
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  • Ale...
  • Taken for 1 to 6 months
  • November 6, 2019

Effexor (venlafaxine) for Depression "Reading reviews online will freak you out about this drug, and as someone who used it for panic disorder and extreme anxiety (as well as depression), these reviews on here definitely terrified me. First off, relax. Taking any new drug for the first time can be scary because your body's adjusting, but freaking out about any little symptom will only make your experience worse. Now on to my experience: The first couple of weeks, I experienced nausea and maybe a bit of sleeplessness, but nothing too crazy. Lost a bit of weight too as it suppressed my appetite. I really do believe this drug helped calm my nervous system enough so that I was able to function normally again, and so far after the first month, I don't experience side effects at all. Don't be scared about all the wacky reviews, people can psych themselves out when influenced by others' opinions."

9 / 10
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  • Lal...
  • Taken for 1 to 6 months
  • August 17, 2021

Effexor XR (venlafaxine) for Generalized Anxiety Disorder "This medicine works. With side effects, yes. But IT WORKS. Tips: Start with 37.5 mg every morning for 7 days. Then replace 37.5 with 75 mg every morning for another 7 days. At the end of the 2nd week you will start to feel 'human' again. Add another 37.5 every afternoon for another 7 days, but not too late in order to avoid insomnia. At the end of the month replace the 37.5 with 75 mg and so you have 150 mg every day with minimum side effects. Anxiety will reduce, sentimental reactions will become more curbed and manageable. You will be yourself again. Remember: be patient and persistent. Stick with it, especially the first month, don't give up. Use some diazepams in order to reduce the anxiety produced by the pill the first weeks! Feel free to ask anything! United we stand!!!"

9 / 10
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Frequently asked questions

  • Joe...
  • Taken for 10 years or more
  • May 10, 2019

Effexor XR (venlafaxine) for Depression "I am a 43-year-old man. I take Effexor XR 150mg since 2000 (yes, I know it is long, but it is better than death). Okay, every 2-3 years I try to be 'med-free', 'normal', and 'out of the stigma', and each time it is the same. I crash. Hard. Each time, I play with my life. From the outside, I look successful, brilliant, intelligent, normal, etc. But I am sick as hell. Sick, but in treatment. I take care of me as I could, and I really don't care about what people think about Venlafaxine now. I don't want to die. Believe me, noradrenaline and serotonin recapture is no garbage. You may need a little help for your brain. Refuse it if you like, but do something about depression before it will do something about you."

10 / 10
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  • Sar...
  • January 28, 2021

Effexor XR (venlafaxine) for Anxiety "I have severe anxiety and regular depression from time to time. I've taken Lexapro, Prozac, and Zoloft. They eventually quit working for me. I had so much anxiety after work that I would like to have an alcoholic drink and sometimes a cigarette to calm my nerves. The problem with this is because alcohol makes anxiety worse if you drink more than two drinks. So it was an endless cycle. I was also getting to the point where I couldn't get off the couch and had no motivation to do anything. Taking a shower was hard for me. I was sleeping a lot! Start out on the Effexor XR 37.5mg dose for about a week or two before moving up to 75 mg. At first, it made me feel really weird, my mind would race, and I was having a hard time sleeping. I stuck it out! I am now taking 75 mg, and I'm so much better! I get up at 6:00 am when I used to sleep until 9:00. I go to the gym 3 days a week, I get dressed up, and now I have a part-time job. Effexor has literally changed my life!"

10 / 10
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  • Ale...
  • October 13, 2020

Effexor XR (venlafaxine) for Depression "Please remember to give Effexor XR a couple of months to work. The first month or even two are going to suck. Why? Remember that the chemicals in your brain are adjusting. We have a chemical imbalance. Be patient and kind to yourself. I was on Lexapro and it worked, but I gained so much weight, so I got off. Not a good idea. Never just go cold turkey! So, after speaking to my doctor, he put me on Effexor, and it has been such a blessing. I’m on 225mg for over 3 years, and while I do have good and bad days because it’s not a miracle pill, you still have to fight the depression and anxiety, but it helps you fight it. Stay strong! It works. Be patient. Don’t be scared."

10 / 10
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  • Smi...
  • October 23, 2020

For Anxiety and Stress "13 years ago, I was started on the usual citalopram, mirtazapine, etc. My son is very ill and immunocompromised, with lots of hospital visits. I was the lowest I've ever been, no interest in anything, and even contemplated walking away from my life (I was very ill mentally) until I started to take venlafaxine. I started in January, and it's now October. I'm a new woman. I can deal with things, I don't overreact, or let my mood affect the household. It's greatly improved my anxiety too, I still have the same fears, but can rationalize things better and more healthily. A bit worried about coming off in the future, but trying to just live in the now. Also lost 5 stone very easily without trying. In my humble opinion, this drug transformed my life. I no longer idolize death as the easier option, as I can actually deal with my emotions now. I feel mentally healthier and enjoy life again instead of just existing."

10 / 10
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  • lin...
  • August 1, 2018

Effexor XR (venlafaxine) for Generalized Anxiety Disorder "Miracle Drug! I advise everyone to stick to it through the first week. For me personally, the first week was awful. Honestly terrible. I was nauseous, disoriented, had short-term memory loss - I felt high/disconnected to reality the first couple of days. After one week, I woke up and was completely fine. I felt like my old normal self (without anxiety/depression). Now I feel very happy, motivated, calm, and most importantly stable! No more mood swings, irritability; as soon as something dark creeps into my mind, I can dismiss it in a moment. I've been on Venlafaxine XR for two months (150mg now) and I feel fantastic. I'm so glad I gave it a go. Although it was my last resort, it was my best resort. I used to be a professional athlete, been vegan for a while, I would meditate, do yoga, and none of that would help at all with my condition. Now, these actions are starting to pay off with the help of this drug. Lots of love to everyone going through hard times. Hope my review helps you ❤️"

10 / 10
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  • don...
  • Taken for 1 to 6 months
  • January 3, 2021

Effexor XR (venlafaxine) for Generalized Anxiety Disorder "After trying Lexapro and Zoloft for depression and anxiety, I decided to give Effexor a try. Effexor was so much easier to start for me, with very few side effects (mild headache, some shakiness, some mild chest tightness). I started at 37.5 mg then bumped up to 75 mg. Once I went to 75 mg, something just clicked and so much fogginess went away. My anxiety improved and my mood is much more stable. This is definitely a much better drug for my chemistry. That being said, don’t be afraid to try it, and don’t take the negative reviews to heart, people are much more likely to leave negative reviews for bad experiences. Best of luck!"

9 / 10
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  • rjb...
  • December 31, 2020

Effexor (venlafaxine) for Depression "I'm on Effexor for depression, anxiety, ADHD. 1-4 weeks. The medication the first few weeks is going to make you excessively sleepy. It is just the nature of the beast. During the first few weeks, ensure that you are taking the time to get a workout in a few times a week and supplement any lethargy with a bit of caffeine. Weeks 5-8. This is where the medication really starts to shine. If you are a male, this drug is ideal for you because it has a less likely chance of causing erectile dysfunction as it is an SNRI and not an SSRI. Your reaction to negative events, to include stressful situations, begins to dramatically change. Instead of having fast-paced thoughts, you have a true sense of peace, less worry, and a newfound sense of overall well-being. I highly recommend this medication if your SSRI is causing you ED, you suffer from anxiety, ADHD, OCD, or depression."

10 / 10
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  • San...
  • Taken for 10 years or more
  • February 27, 2024

Effexor XR (venlafaxine) for Anxiety "I have been on Effexor for over 15 years. I have taken Wellbutrin (did not like) and Lexapro (it helped) but would always come off as soon as I would feel better. Once my PCP put me on this and I finally felt like a real person, in 34 years I knew I would never come off. My doctor explained to me that if I had a heart condition, I would continue to take meds for my heart. I have an anxiety condition that I think is hereditary. My grandmother, mother, me, and now my son all suffer from it. I will always treat my anxiety from now on. I will not come off my meds ever again. What I have experienced in the past is when my anxiety came back, each time it would come back worse than the time before. People that have never suffered from anxiety will never understand how debilitating it is. After suffering with this my whole life and then when I finally felt normal with no worry for the first time, it is hard to even put into words. Do not wait, take it."

10 / 10
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  • Cor...
  • Taken for 1 to 6 months
  • July 23, 2021

For Anxiety and Stress "I have been on venlafaxine for 10 weeks after a cancer diagnosis. I was about to give up on it when I got to eight weeks & asked the doctor if I could try something else, but he told me to stick with it. I'm so glad I did! I had to go up to 300mg, so that's quite high for anxiety, but now I'm feeling so much better. The worst part was the side effects, but that's soon forgotten when you start to feel yourself again. So anyone just starting, don't give up. I have operations, chemo still to face but feel so much stronger than I did."

10 / 10
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  • Sar...
  • Taken for 1 to 6 months
  • March 14, 2020

Effexor XR (venlafaxine) for Anxiety "Effexor is helping me calm down and it’s helping my relationship with my boyfriend. I got put on it for my agitation, irritability, anxiety, social anxiety. I am no longer snappy and argumentative. I know people say it’s hard to withdraw from but it’s saving my life and I plan to stay on it for a long time. Thumbs up."

10 / 10
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308 Report
  • Sta...
  • September 20, 2020

Effexor XR (venlafaxine) for Generalized Anxiety Disorder "I have always been a more anxious person, but in college, I experienced sensations of extreme anxiety (detached from reality, drenched, sweating, shaking) and almost passed out. This lasted for days. I went to the ER and was told it was a result of extreme stress and was given an Ativan. This continued for a year anytime I felt mildly stressed and went to the doctor. I had a horrible reaction to Celexa, it sedated me. Zoloft helped some, but not great, and Effexor. Effexor was difficult at first, I was fatigued and dizzy for about 2 weeks. In the fourth week, the good effects of the medication hit me, and it felt like I could breathe again. I am an even better version of myself, by that I mean happier and calmer. I don’t experience the physical symptoms on a daily basis. I’m more confident and worry less about stressful situations. It took me trying 3 different meds to feel this way. Please have hope and keep pushing through."

10 / 10
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  • Tep...
  • June 4, 2020

Effexor XR (venlafaxine) for Depression "I had severe anxiety in 2016. It was truly crippling. Along with panic attacks and thinking I was dying all the time, I experienced depersonalization/derealization every day. Effexor XR truly saved my life. I take my pills at night, and if I miss one dose, I know immediately the next day by how I feel. It’s a horrible feeling. I also described it as my head was skipping, but I see others describe it as brain zaps. That’s truly what it feels like. Besides that though, this medication changed everything for me."

9 / 10
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  • Ypi...
  • Taken for less than 1 month
  • May 31, 2018

Effexor XR (venlafaxine) for Anxiety "I posted on May 19, and this is my update. So, I stopped sertraline and started taking Effexor 75 mg capsules. The doctor advised to stop sertraline slowly, so the first week I took Effexor 75 mg and half of sertraline, which is 50 mg. The second week I took Effexor 75 mg and sertraline 25 mg. And now just Effexor, 75 mg of Effexor (venlafaxine). I feel so much better. My anxiety has almost stopped, and I remind myself to take deep breaths. I'm sleeping better, and I’m pushing myself a lot more. I refuse to sleep during the day, and all that is helping me. I’m posting this because I know how it feels to feel helpless. So everyone, keep pushing through this. Keep your head up, keep praying, and stay positive. Love you all and good luck!"

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  • ksa...
  • Taken for 6 months to 1 year
  • August 23, 2020

Effexor XR (venlafaxine) for Anxiety "If you are reading these reviews and having anxiety about taking a medicine, I get it. The best advice I can offer is to go into it with a mindset that this is going to help you. In the scariest time of my life when I had panic disorder, was having trouble eating and sleeping, Effexor saved me. I took Lexapro, terrified to take it, and had horrible reactions. This drug makes me feel like myself minus panicking. I didn't feel like it kicked in until about 3 months. The only thing is it does make you feel a bit more 'flat', but I was a little over-emotional so it helped with this. I've been on this for almost a year and would recommend trying it."

8 / 10
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  • Pan...
  • March 22, 2021

Effexor XR (venlafaxine) for Anxiety "Since my Middle East deployment, I've dealt with panic attacks. It got to the point where I was severely agoraphobic, not even able to leave my home to drive to the gas station a mile away. VA SSRIs never worked. After being brought to the local ER due to severe brain fogginess, the ER physician suggested norepinephrine might be the issue, not the serotonin. The doctor also took it and said to give Effexor XR a go. Three weeks later, I believe he may be right. I no longer focus on every little beat my heart makes. I can drive again. I can go places. I'm not perfect yet but major improvements have happened. The fogginess is still there a tad bit but not nearly as horrible as it was three weeks ago. It's not even fully in my system yet. If you have taken all the SSRIs there are with no results, try this. It works. I've heard withdrawals are really bad but I'm not worried about that right now. It just feels good to feel a bit more normal again. Praise God. P.S. I'm still able to 'perform' with the wife. Another huge relief."

9 / 10
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  • Wil...
  • Taken for 5 to 10 years
  • May 2, 2020

For Anxiety and Stress "I've been taking venlafaxine (Effexor XR) for over 7 years and I'm giving it a rave review! It's the best medication I've ever used for my anxiety disorders and I've tried almost all the SSRIs. As added bonuses, it also relieved my depression, and the only side effect I had was a mild headache for the first few days after I started it. I can't say how happy I am with this medication! It's turned my life around."

1 / 10
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  • Mon...
  • Taken for 1 to 6 months
  • November 20, 2019

Effexor (venlafaxine) for Major Depressive Disorder "I know the reviews are scary, and hey, this medication is not for everyone. Our bodies will all react differently. Prior to Effexor, I took Lexapro, but it didn't help me whatsoever. The only thing it helped me with is yawning awkwardly every other minute. My doctor suggested Effexor, and it completely helped me get out of the hole I was in. I was able to think clearly, feel joy, laugh, and really be present. My anxiety went down tremendously, and this, with the combination of therapy, helped me lose 70 lbs. I got off Effexor, and did it the healthy way, I did it slowly...and I was fine! No crazy withdrawals. So yes, people, it's possible to be on it and off of it, and still be okay. :)"

9 / 10
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283 Report
  • My ...
  • Taken for 6 months to 1 year
  • July 26, 2014

Effexor XR (venlafaxine) for Generalized Anxiety Disorder "Effexor has changed my life. I have always had bad anxiety, but it got out of control after a traumatic event 3 years ago. Finally decided I needed some help and was prescribed Effexor. I doubted it would help - I tried Lexapro a few years before and had awful panic attacks. I am so glad I was wrong and gave Effexor a chance! My anxiety has greatly decreased, and I'm now able to function and think about things other than worries. I had some unexpected benefits too, including reduced social anxiety, I'm more motivated, increased confidence, and a general feeling of happiness and well-being. No real negative side effects - I have lost about 15 pounds and I was a normal weight. I feel like this is how I should have been feeling all my life."

10 / 10
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  • Taw...
  • Taken for 1 to 6 months
  • February 18, 2020

Effexor XR (venlafaxine) for Depression "I take 150mg time-released Effexor. I am dealing with a head injury for 6 months now. I have been on Effexor since. I have no side effects, and it has really helped me with my anxiety, nervousness, and depression. This medicine is such a lifesaver. I can go to work and be around people. I don’t know where I would be without this medication."

10 / 10
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  • Luc...
  • January 6, 2021

For Anxiety and Stress "Venlafaxine changed my life, after only taking it for 2 months. The side effects were horrible at first. I had headaches and would shake or tremble when anxious, and I got extremely itchy. When you suffer from depression, GAD, PTSD, and OCD, it's a small price to pay because I started to see a change in my mood and my anxiety. For the first time in my life, my anxiety was almost gone, I could go out in public and engage in conversation for the first time in my life. I started on 75mg and I am still on it 6 months after. Lexapro made me a slow zombie and did nothing for my anxiety, it only helps for depression. A lot of reviews have negative feedback, but if you are in a bad place, push through the side effects because it's worth it, they do go away. This is the only antidepressant that doesn't make me a zombie during the day, I feel more awake. Stay strong."

8 / 10
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  • Mit...
  • August 9, 2014

Effexor XR (venlafaxine) for Anxiety "Have suffered from bouts of severe anxiety over the last few years that would leave me bedridden, suicidal, unable to work or eat. Tried Zoloft, Celexa, Lexapro, Cymbalta, Luvox, and honestly thought nothing would ever work for me. All made me worse. My psych doctor wanted to try Effexor XR, but I was worried about withdrawing from it - after trying everything else, I finally agreed. It has taken a month to feel a difference. I'm enjoying things again, not chewed up by horrible anxiety. I'm actually HAPPY?! The first month on it was so challenging - very low, anxious, exhausted, nauseous. But now no side effects. I feel like a light has gone on. I am getting my life back. I could sob with relief. I truly believed I'd never get better, but here I am."

8 / 10
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  • Cle...
  • March 2, 2021

Effexor XR (venlafaxine) for Anxiety "I’ve had depression and anxiety my whole life, and I’m diagnosed with major depression and generalized anxiety disorder. I tried all the other antidepressants, but I didn’t really know if they worked or not. A new doctor slowly tapered me up on Effexor. That was about a year ago... The side effects weren’t terrible, some nausea and insomnia for like a week, and then after that, the side effects were gone. I feel so much better, honestly, and I’m not just saying that because with Lexapro and Cymbalta, I never knew if they were working or not. Effexor helps with my anxiety a lot, rumination, and this is the first winter I’ve enjoyed in at least a decade. Also, I have an eight-year-old, a four-year-old, and a three-month-old, all girls, and virtual schooling is still on, so it definitely helps me be more patient and takes the edge off so I don’t yell and scream in a fit of exasperation. I was also afraid of getting postpartum, but honestly, I haven’t felt any of that. Thank the Lord."

9 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.