Tranylcypromine and Dry Mouth: What Users Say

• Lis...
• July 16, 2019

For Depression "I have been on Parnate for 21 years and still going strong. I had severe treatment-resistant atypical depression for three years. Over that time, they put me on 10 different antidepressants in various combinations, and nothing worked. I did my own research and made my psychiatrist put me on it. Within a week, I was fine. I would, without a doubt, be dead without Parnate. I regularly eat aged cheese and cured meats, etc., and have never had any food reaction. However, if I drink beer or red wine, I do have a minor reaction - sounds weird, but I grind my teeth and can just tell it’s reacting with the Parnate. Side effects are very minimal - dry mouth; bit of agitation, etc. (though that could be from my anxiety issues - which are also significantly reduced on Parnate). The agitation was worse when I was on 60mg, but now I’m down to 30mg it’s fine. I have tried going off it to see what happened, and the depression came back with a vengeance within a few days!"

• use...
• Taken for 2 to 5 years
• July 31, 2016

For Depression "I have tried many medications for major depressive disorder, SSRIs, TCAs, as well as cognitive behavioral therapy. All of which helped to some degree, but I was never quite functioning as well as I would have hoped. Depression was ruining my life, and I was becoming very discouraged and disappointed because I had tried so many medications and other treatments, suicide was a thought I had every hour of every day. Now, every single day I am thankful I found Parnate. I get a little dizziness, some dry mouth, and some loud heartbeats, but that is an insignificant cost to pay to have the will to live back once again. If you are struggling with depression after trying many treatments, please ask your doctor about an MAOI. Best of luck!"

• Anonymous
• November 19, 2010

For Depression "Side effects are terrible. They include diarrhea, dry mouth, in my case weight gain, it also made me agitated. I have been trying to withdraw from it and now have neuromuscular symptoms of cramping, teeth grinding, eye blinking."