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Nucynta User Reviews & Ratings (Page 3)

Nucynta has an average rating of 6.2 out of 10 from a total of 269 reviews on Drugs.com. 51% of reviewers reported a positive experience, while 30% reported a negative experience.

Reviews for Nucynta

  • Roscoe
  • March 2, 2014

For Pain "After taking the second pill, I had to go to the ER. I couldn't control my emotions, I broke down, bawling like a baby for no reason, just an uncontrollable need to cry. I never had these side effects with opiate pain relievers."

1 / 10
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71 Report
  • half...
  • Taken for less than 1 month
  • November 12, 2013

For Pain "I'm taking 75 mg qid for severe spinal degeneration as well as other issues. In the past, I used Dilaudid, Percocet, and MS Contin. Nucynta works great for pain, but I am more tired than with other drugs. My insurance company denied approval, so I faxed them a letter explaining why I needed it, and they approved it 10 minutes after the fax was sent. Thank God!"

9 / 10
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72 Report
  • Steve
  • Taken for 1 to 2 years
  • September 3, 2018

For Pain "On 50 mg three times a day for 2 years. I took it to treat Reflex Sympathetic Dystrophy, also known as Complex Regional Pain Syndrome. Tolerated well, and it seemed to help a little, just enough to take the edge off the pain. After two years, it stopped working, so the dose was increased to 75 mg three times a day, which caused the side effect of Serotonin Syndrome. I had to be hospitalized and almost died from extreme acute hypertension! Almost a year later and still suffering from the incident. It ruined my life. Be extremely careful! My doctor will not prescribe it anymore for any of his patients because of the severity of adverse side effects he has witnessed in some of his patients. And if your doctor does increase your dose or add a new drug, check for interactions in case they don't know."

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  • Major...
  • June 24, 2019

For Pain "I am on a trial of Nucynta medication 50 mg every 6 hours. I have been on several different pain medications, and lately they have not been working due to a worsening condition. I have fibromyalgia, DDD (degenerative disc disease), and arthritis in my cervical and lumbar spine, as well as a tumor that caused me to have a near-total mandibulectomy, which is now the main source of my pain. The first few days I felt very dizzy, but surprisingly my pain level is so much better, I cannot believe it! I hope this continues. The only downside is the cost. My co-pay was $53, and that was for 7 days' worth! If this works, then I have to pay another $53! So this works for me, but the cost does not, so I am not sure how this will all work out."

8 / 10
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41 Report
  • jgarr...
  • April 2, 2010

For Pain "I have only been taking Nucynta for about a week. It was prescribed to me for severe pain caused by nerve regeneration in my lumbar and sacral joints. I have been very close to being completely pain-free thanks to my doctor's willingness to try this medicine. The only drawbacks I've had were pounding headaches the first couple of days. Through God's help and the right medicines, I'm feeling much better."

8 / 10
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87 Report

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  • Cockf...
  • September 7, 2015

For Pain "I have a cyst along my spine with a messed-up disc. The codeine-based medicine's side effects were terrible. Nucynta 75 mg, 3 times a day, works wonders. I only take it when I do a lot of work, which affects my lower back. My wife likes me to take it as I am not as grumpy. Like all medicines, some work for certain people and not for others. For me, Nucynta and Demerol work best with minimal side effects."

9 / 10
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  • kadee...
  • Taken for less than 1 month
  • March 24, 2016

For Pain "I was prescribed this medication because I'm allergic to some of the more common painkillers. I took it a total of 2 weeks, daily as prescribed. I had horrible hallucinations, became severely depressed, had insomnia, and I felt like every ounce of joy was sucked out of my body. I had the strangest experiences with this medication. I felt like I left my body. Once, I saw myself jumping off the balcony. I was clearly hallucinating. It was the worst experience from a medication I've ever had. I was extremely distraught but had no idea why. My husband freaked out and rushed me to the doctor. I was told that it was side effects of the medication. I had to be weaned off of it by a doctor. Even under the doctor's care, I had horrible withdrawal symptoms."

1 / 10
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  • Miblu...
  • May 20, 2014

For Pain "After orthopedic foot surgery, I was prescribed Percocet. After side effects, my medication was changed to Nucynta. For me, I prefer the Nucynta. My problems with constipation went away immediately. I had a little itchiness from Nucynta, but nothing I couldn't tolerate. I got much better pain relief from the Nucynta too. Good thing I have insurance as it's very pricey."

10 / 10
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67 Report
  • SprGd...
  • October 17, 2013

For Pain "I have been taking Nucynta for about 2 years now. This medicine seems to be helping with my back pain. I started at the low dose of 50 mg, then went to 75 mg and am now taking 100 mg every 4-5 hours, as well as taking the 100 mg Extended Release tablets every 12 hours. They work great, although my only complaint would be that they make me sweat profusely when doing any activity that includes work. I even start to pour sweat when just sitting after 1 hour of taking it. As well, it makes me very tired. I find myself trying hard to keep my eyes open when I'm sedentary."

9 / 10
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68 Report
  • chanel
  • Taken for less than 1 month
  • April 10, 2013

For Pain "I tried this medicine at 50 mg up to 4 times per day and it is very helpful for chronic neck and shoulder pain I have suffered for years. There are no highs and lows like other pain medicines. I also had a nerve block injection to the area and that removed the pain 100%. I highly recommend it and a nerve block. It scared me too, but it worked."

9 / 10
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70 Report
  • A Dude
  • Taken for 2 to 5 years
  • January 25, 2013

For Pain "I have been on Nucynta for 2 years following a ten to twelve foot fall. Nucynta is without a doubt the best pain medication I have ever been prescribed. It works well on my severe shoulder, back, and neck pain. Without the nasty side effects of other opiates I was taking, such as Hydrocodone. I am able to stay alert and I have not built up a tolerance to it. Nucynta has been a game changer for me."

10 / 10
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  • kitty...
  • Taken for less than 1 month
  • March 10, 2019

For Pain "I was given this medication 2 weeks ago, 50 mg 3 times a day. On week 1, I felt significant relief from pain, but in the second week, 7 days later, I became stomach sick, vomiting and diarrhea, nauseous, and my back pain (3 fractured lumbar) came back with a vengeance, feeling the worst pain ever, and I'm still taking the prescribed dose. What's up with that??? I'm so disappointed because I thought, after 8 years of suffering from chronic pain day after day, that I finally found something to address this pain. But no, it lasted all of 3-4 days and now I'm feeling more pain and less relief from the same drug... back again to see the doctor."

3 / 10
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40 Report
  • Born
  • March 22, 2015

For Pain "Awesome drug with no narcotic hangover. With radiation damage to all the organs that I still have, the pain never goes away. Nucynta (600 mg/day) has allowed me to have a tolerable life and work much better. Best medicine since Vioxx (which was removed from the market). My pain level is down to a 6 or 7 now. Very pleased. Much better than traditional opioids that cause highness, mental, and go problems. Clear-headed on this med."

9 / 10
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  • Holyc...
  • July 26, 2013

For Pain "I started Nucynta the first time and was on a low dose of 25 mg of Zoloft. I had been taking hydrocodone 10 mg for several years. The reason for Zoloft was for minor depression that the hydrocodone causes. The first two pills I had of Nucynta caused insomnia, weird dreams, and a bit of anxiety. Also, I had shivering and felt so hot I thought I was burning up. Even though my rheumatologist/pain specialist suggested I give it 5 days, I did not. Well, a couple of weeks later, I am trying it again. So far, so good. My pain level is better but not yet all gone. I did have to take hydrocodone early in the morning as I started having withdrawal symptoms from not taking it. I was told I would not. I'm glad for Nucynta. I have neuropathy, fibromyalgia, and two kinds of arthritis."

8 / 10
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  • 51and...
  • July 1, 2017

For Pain "Serotonin syndrome!!! I take an antidepressant, Cymbalta 60 mg, Trazodone 50 mg, gabapentin up to 900 mg because I have CRPS and literally cannot walk due to a surfing accident that almost paralyzed me 10 years ago. DO NOT TAKE THIS MED IF YOU'RE ON any kind of antidepressant!!! It will cause you to start shaking, your heart pounds, you're dizzy, sick, and you could actually die from this! This med does nothing for my pain! If you do take it with an antidepressant, make sure you have a Narcan kit!! God bless us who depend on these doctors!!"

1 / 10
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  • Ghett...
  • Taken for 1 to 6 months
  • May 1, 2016

For Pain "I'm not sure why this medication is considered a Schedule II 'narcotic.' Perhaps having been prescribed Oxycodone, Hydromorphone, and Fentanyl in the past is a factor in forming this opinion, but I have been fortunate enough to find a specialist willing to treat fibromyalgia-related pain with Nucynta. This medication does not give me any of the usual negative opioid side effects, nor the weird SSRI/SNRI type mental side effects of Tramadol. Nausea is rare and possibly unrelated, no itching, or lack of mental clarity. I can see why it would be inadequate for post-surgical or trauma-induced pain, but it works perfectly for my current state of managing physical therapy after a long period of inactivity."

10 / 10
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  • Chris...
  • August 23, 2016

For Pain "I've been on Nucynta 150 mg for months. I feel no relief of my pain, which is severe in my back. This drug doesn't even make me sleepy, it's as if I'm taking nothing! I feel it is worthless as a form of pain management!"

1 / 10
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52 Report
  • Vee
  • Taken for less than 1 month
  • July 20, 2016

For Pain "For fibromyalgia - This drug did absolutely nothing for me, like taking a placebo pill. No pain relief WHATSOEVER. I was tried on 200 mg ER. I noticed that after about an hour and a half after taking a dose, I would pass out asleep for about an hour and then wake up not remembering that I even fell asleep. Very strange. I'd wake up in full-blown pain, and I also had stomach cramps, which made my pain levels and overall experience much worse. I was so hopeful for this drug because it's said to treat diabetic neuropathy, which I also have in addition to the fibromyalgia, but it didn't do anything at all to relieve my pain. You'd be better off taking Tylenol instead of this, that's how terrible it is."

1 / 10
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  • ROBERT...
  • Taken for less than 1 month
  • February 27, 2016

For Pain "Pain doc just switched me to Nucynta ER 150 mg - twice daily... after making the rounds of other meds. I was on 4 mg Dilaudid before this - morphine, oxycodone - all losing some of their effect after a while; but they ALL worked better than this tapentadol stuff. I am a cancer survivor with a host of other conditions - arthritis, carpal tunnel, cervical neuropathy, and lower back pain. Not only is it having no effect on the pain - I can't sleep - have a pounding headache and now can't urinate at all (enlarged prostate). Don't like this med at all..."

1 / 10
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  • Jayce
  • October 10, 2013

For Pain "I started Nucynta 100 mg 3 times a day because I have severe back problems. Norco and Vicodin were not working. The first day I was on it, it took about an hour to kick in (around 12 AM, I got my prescription at 11 PM). I had bizarre and violent dreams. I took it before work (I didn't drive) and I have a desk job. I spent most of the day drooling. On day 2, I had a great night's sleep, with no bizarre dreams, and fell asleep without any problem. I went to work and was hot and sweaty (the office was at 69 degrees and it was raining), with the worst dry mouth you could imagine. I had no appetite and drank a ton of water. On day 3, I experienced diarrhea, sweating, and no appetite. As for pain management, it worked better than Vicodin, but I still feel a burning sensation."

5 / 10
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64 Report
  • axial...
  • Taken for less than 1 month
  • March 8, 2013

For Pain "The first 4 days were great, no pain and no lethargy. Day 5 began with stomach upset and hot flashes. Day 6 brought anxiety ending in severe depression and a psychotic break. All resolved after cessation in 24 hours."

1 / 10
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  • Himalay
  • March 2, 2014

For Pain "I was given a single dose of Nucynta for pain after hip replacement surgery. The side effects were just weird, a feeling of being disconnected from my body and mental confusion. I was also nauseous with vomiting. I never had this effect with Demerol, Percocet, or Valium. Maybe I was allergic to it."

1 / 10
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  • Mystery...
  • Taken for 1 to 6 months
  • December 1, 2015

For Pain "I had shoulder surgery back in July 2015. I was prescribed 50 mg every 6 hours for pain. I took it just a couple of days because I did not need much of it, and the side effect, dry mouth, drove me insane. Fast forward to November 2015. I'm still experiencing severe pain in my shoulder, 9/10. So I started using these sparingly whenever I feel like I want to be pain-free. It works great, and the dry mouth is worth the pain-free time I get."

9 / 10
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53 Report
  • PitBu...
  • Taken for 2 to 5 years
  • January 26, 2016

For Pain "I have been in constant pain for 17 years (since I was 12) RSD, chronic migraine, fibromyalgia, myofascial pain syndrome, Sjögren's, and several other things. Tried everything to manage the pain and gain some of my life back. The only thing I found that helps is Nucynta. I have been on it for about 4 years, (1) 100 mg tablet every 4 hours. It's a love/hate relationship. It's the only thing that helps my pain, but I hate waking up every morning going through withdrawal because I've been on it so long. I tried the ER, but it wasn't as effective. I know it's not good to be on it for so long, but I'm at a loss for any other options to try, and it really does help me be more functional than I was without it. Besides the withdrawal, I have not had side effects."

8 / 10
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  • senec...
  • Taken for less than 1 month
  • December 11, 2016

For Pain "I have severe, constant pain following 4 serious car accidents (none my fault) over 14 years. I was taking OxyContin 10 mg x5 per day, and my Dr. recommended I try Nucynta. I don't know why. It was more expensive and not available in a generic form. After three days, I felt it was less effective in controlling my pain. On the fourth day, I woke up and felt I had nothing to live for and my life had no meaning. I have depression and PTSD caused by the accidents, but these conditions are well controlled by other medications. I normally don't have these thoughts. I believed this was a side effect of the Nucynta, so I immediately stopped taking it, and those thoughts went away right after."

5 / 10
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48 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.